Photocatalytic α-Nucleophilic Fluorination of α,β-Unsaturated Carbonyl Compounds

IF 4.7 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-08-02 DOI:10.1039/d5qo00877h

Fang Wang, Jie Gong, Jian-Ping Qu, Yan-Biao Kang

引用次数: 0

Abstract

We report redox-neutral photocatalytic α-nucleophilic fluorination of α,β-unsaturated carbonyl compounds, in which an α-carbonyl cation is involved, under mild conditions. The protocol offers practical and efficient access to α-fluorinated carbonyl compounds and has demonstrated potential applications in the late-stage fluorination of bioactive molecules.

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α，β-不饱和羰基化合物的光催化α-亲核氟化反应

我们报道了在温和条件下氧化还原中性光催化α，β-不饱和羰基化合物的α-亲核氟化，其中α-羰基阳离子参与。该方案为α-氟化羰基化合物提供了实用和高效的途径，并已证明在生物活性分子的后期氟化中有潜在的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.