A prognostic score based on early recurrence-related factors for hepatocellular carcinoma patients with microvascular invasion after hepatectomy.

IF 1.8 3区医学 Q2 SURGERY

Langenbeck's Archives of Surgery Pub Date : 2025-08-01 DOI:10.1007/s00423-025-03823-4

Hongyu Li, Junyi Shen, Tianfu Wen

{"title":"A prognostic score based on early recurrence-related factors for hepatocellular carcinoma patients with microvascular invasion after hepatectomy.","authors":"Hongyu Li, Junyi Shen, Tianfu Wen","doi":"10.1007/s00423-025-03823-4","DOIUrl":null,"url":null,"abstract":"Purpose: We aimed to construct a simple risk score to stratify individuals with distinguished prognosis for HCC patients with microvascular invasion (MVI).Methods: 265 qualified patients were retrospectively analyzed. A prognostic score was constructed using predictors associated with early recurrence (ER). Based on the HR value, AFP > 400 ng/ml and hepatitis B viral e antigen (HBeAg) positivity were assigned as 1 point, satellite nodule was assigned 2 points. There were five subgroups (score 0/1/2/3/4). Due to similar RFS in score 2/3/4 subgroups, we merged these into a single cohort (group C), while maintaining score 0 as group A and score 1 as group B.Results: MVI (+) HCC patients who developed ER had dramatically decreased overall survival (OS) compared with those who did not(P < 0.001). Based on the result of multivariable analysis, MVI (+) HCC patients with satellite nodules, positive HBeAg or serum alpha-fetoprotein above 400ng/ml were more likely to developed ER. The 3-year recurrence free survival rates for the group A, group B and group C were 42.7%, 26.4% and 9.3%, respectively. The 3-year OS rates for group A, group B and group C were 65.4%, 48.7% and 26.9%, respectively (p < 0.001). A higher score was correlated with significantly worse prognosis (p < 0.001). Furthermore, the prognostic score distinguished the prognosis of MVI (+) HCC patients independently of liver cirrhosis (p < 0.001).Conclusions: The prognostic score consisted of ER-related factors effectively predict prognosis for MVI (+) HCC patients after hepatectomy.","PeriodicalId":17983,"journal":{"name":"Langenbeck's Archives of Surgery","volume":"410 1","pages":"237"},"PeriodicalIF":1.8000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316790/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Langenbeck's Archives of Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00423-025-03823-4","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"SURGERY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: We aimed to construct a simple risk score to stratify individuals with distinguished prognosis for HCC patients with microvascular invasion (MVI).

Methods: 265 qualified patients were retrospectively analyzed. A prognostic score was constructed using predictors associated with early recurrence (ER). Based on the HR value, AFP > 400 ng/ml and hepatitis B viral e antigen (HBeAg) positivity were assigned as 1 point, satellite nodule was assigned 2 points. There were five subgroups (score 0/1/2/3/4). Due to similar RFS in score 2/3/4 subgroups, we merged these into a single cohort (group C), while maintaining score 0 as group A and score 1 as group B.

Results: MVI (+) HCC patients who developed ER had dramatically decreased overall survival (OS) compared with those who did not(P < 0.001). Based on the result of multivariable analysis, MVI (+) HCC patients with satellite nodules, positive HBeAg or serum alpha-fetoprotein above 400ng/ml were more likely to developed ER. The 3-year recurrence free survival rates for the group A, group B and group C were 42.7%, 26.4% and 9.3%, respectively. The 3-year OS rates for group A, group B and group C were 65.4%, 48.7% and 26.9%, respectively (p < 0.001). A higher score was correlated with significantly worse prognosis (p < 0.001). Furthermore, the prognostic score distinguished the prognosis of MVI (+) HCC patients independently of liver cirrhosis (p < 0.001).

Conclusions: The prognostic score consisted of ER-related factors effectively predict prognosis for MVI (+) HCC patients after hepatectomy.

Abstract Image

查看原文本刊更多论文

基于肝切除术后微血管侵犯肝细胞癌患者早期复发相关因素的预后评分。

目的：我们旨在建立一个简单的风险评分，对HCC微血管侵犯（MVI）患者预后不同的个体进行分层。方法：对265例符合条件的患者进行回顾性分析。使用与早期复发（ER）相关的预测因子构建预后评分。根据HR值，甲胎蛋白> 400 ng/ml及乙型肝炎病毒e抗原（HBeAg）阳性评分为1分，卫星结节评分为2分。分为5个亚组（评分0/1/2/3/4）。由于评分为2/3/4亚组的RFS相似，我们将其合并为单一队列（C组），同时维持评分为0分的a组和评分为1分的b组。结果：与未发生ER的MVI (+) HCC患者相比，发生ER的MVI (+) HCC患者的总生存期（OS）显著降低(P)结论：由ER相关因素组成的预后评分可有效预测肝切除术后MVI (+) HCC患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Langenbeck's Archives of Surgery 医学-外科

CiteScore

3.30

自引率

8.70%

发文量

342

审稿时长

4-8 weeks

期刊介绍： Langenbeck''s Archives of Surgery aims to publish the best results in the field of clinical surgery and basic surgical research. The main focus is on providing the highest level of clinical research and clinically relevant basic research. The journal, published exclusively in English, will provide an international discussion forum for the controlled results of clinical surgery. The majority of published contributions will be original articles reporting on clinical data from general and visceral surgery, while endocrine surgery will also be covered. Papers on basic surgical principles from the fields of traumatology, vascular and thoracic surgery are also welcome. Evidence-based medicine is an important criterion for the acceptance of papers.