{"title":"Unveiling Alpha Amylase Dynamics in Peri-Implant Crevicular Fluid: A Comparative Analysis across Peri-Implant Health and Disease Spectrums.","authors":"Ritvija Cinderella, Arvina Rajasekar","doi":"10.1615/JLongTermEffMedImplants.2025056747","DOIUrl":null,"url":null,"abstract":"<p><p>This study aimed to evaluate the levels of alpha amylase in patients with healthy dental implants, peri-implant mucositis, and peri-implantitis. A cross-sectional study was conducted involving 75 implant sites, divided into three groups of 25: peri-implant health, peri-implant mucositis, and peri-implantitis. Peri-implant crevicular fluid was collected from each selected implant site and analyzed for alpha amylase levels using an ELISA kit. The resulting alpha amylase concentrations were statistically compared between the groups. The mean concentration of alpha amylase was lowest in healthy sites (9.57 ± 1.59 ng/mL), compared with peri-implant mucositis (14.90 ± 2.62 ng/mL) and peri-implantitis (20.67 ± 4.55 ng/mL), with the differences being statistically significant (P = 0.00). Furthermore, multiple comparisons revealed a statistically significant distinction between the groups (P = 0.000). Elevated levels of alpha amylase in peri-implant disease sites, as opposed to healthy sites, suggest its potential as a predictive marker for peri-implant diseases.</p>","PeriodicalId":16125,"journal":{"name":"Journal of long-term effects of medical implants","volume":"35 3","pages":"91-96"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of long-term effects of medical implants","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1615/JLongTermEffMedImplants.2025056747","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Dentistry","Score":null,"Total":0}
引用次数: 0
Abstract
This study aimed to evaluate the levels of alpha amylase in patients with healthy dental implants, peri-implant mucositis, and peri-implantitis. A cross-sectional study was conducted involving 75 implant sites, divided into three groups of 25: peri-implant health, peri-implant mucositis, and peri-implantitis. Peri-implant crevicular fluid was collected from each selected implant site and analyzed for alpha amylase levels using an ELISA kit. The resulting alpha amylase concentrations were statistically compared between the groups. The mean concentration of alpha amylase was lowest in healthy sites (9.57 ± 1.59 ng/mL), compared with peri-implant mucositis (14.90 ± 2.62 ng/mL) and peri-implantitis (20.67 ± 4.55 ng/mL), with the differences being statistically significant (P = 0.00). Furthermore, multiple comparisons revealed a statistically significant distinction between the groups (P = 0.000). Elevated levels of alpha amylase in peri-implant disease sites, as opposed to healthy sites, suggest its potential as a predictive marker for peri-implant diseases.
期刊介绍:
MEDICAL IMPLANTS are being used in every organ of the human body. Ideally, medical implants must have biomechanical properties comparable to those of autogenous tissues without any adverse effects. In each anatomic site, studies of the long-term effects of medical implants must be undertaken to determine accurately the safety and performance of the implants. Today, implant surgery has become an interdisciplinary undertaking involving a number of skilled and gifted specialists. For example, successful cochlear implants will involve audiologists, audiological physicians, speech and language therapists, otolaryngologists, nurses, neuro-otologists, teachers of the deaf, hearing therapists, cochlear implant manufacturers, and others involved with hearing-impaired and deaf individuals.