The value of vaginal cytology for postoperative surveillance of endometrial cancer.

IF 2.8 3区医学 Q3 ONCOLOGY

International Journal of Clinical Oncology Pub Date : 2025-10-01 Epub Date: 2025-07-31 DOI:10.1007/s10147-025-02843-w

Yuko Watanabe, Eiji Kobayashi, Tatsuo Masuda, Mamoru Kakuda, Satoshi Nakagawa, Kosuke Hiramatsu, Tadashi Iwamiya, Shinya Matsuzaki, Eiji Nakatani, Yutaka Ueda

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引用次数: 0

Abstract

Background: The value of conducting vaginal cytology surveillance after endometrial cancer (EC) surgery has not been fully established, yet in Japan it is still performed routinely in many institutions. We have retrospectively examined its diagnostic and prognostic values.

Methods: We studied 759 EC cases that underwent hysterectomy at our hospital in Osaka, Japan from January 2010 to December 2019. Information on the clinicopathological factors at the time of initial and postoperative treatments, and the sites and diagnostic timing of recurrences were extracted from medical records and analyzed.

Results: Recurrences from primary EC were observed in 11.2% of the patients (85/759). In 23.5% of the cases (20/85), the recurrence included a vaginal component. The two most common single-sites of recurrence were vagina (14.1%, 12/85) and lung (12.9%, 11/85). The diagnosis of vaginal recurrence was made from symptoms and gynecological examination in 14 of the 20 cases. Only one was diagnosed solely by vaginal cytology; in that case, macroscopic lesions appeared two months after obtaining the abnormal cytology.

Conclusions: We found that, in postoperative follow-up surveillance for EC, most cases of vaginal recurrence were first diagnosed by a careful pelvic examination. For current routine postoperative practice, monitoring critical symptoms and conducting careful gynecological examinations has been shown to be more important than cytological examinations.

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阴道细胞学检查对子宫内膜癌术后监测的价值。

背景：子宫内膜癌（EC）手术后阴道细胞学监测的价值尚未完全确定，但在日本，许多机构仍将其作为常规检查。我们回顾性研究了其诊断和预后价值。方法：我们研究了2010年1月至2019年12月在日本大阪本院接受子宫切除术的759例EC病例。从医疗记录中提取和分析初始和术后治疗时的临床病理因素信息，以及复发的部位和诊断时间。结果：原发性EC的复发率为11.2%（85/759）。在23.5%的病例（20/85）中，复发包括阴道成分。两个最常见的单部位复发为阴道（14.1%,12/85）和肺部（12.9%,11/85）。20例中有14例经症状和妇科检查诊断为阴道复发。只有一人是通过阴道细胞学诊断的；该病例在细胞学检查异常两个月后出现宏观病变。结论：我们发现，在EC的术后随访监测中，大多数阴道复发病例首先是通过仔细的骨盆检查诊断出来的。对于目前的常规术后实践，监测关键症状并进行仔细的妇科检查已被证明比细胞学检查更重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Clinical Oncology 医学-肿瘤学

CiteScore

6.80

自引率

3.00%

发文量

175

审稿时长

2 months

期刊介绍： The International Journal of Clinical Oncology (IJCO) welcomes original research papers on all aspects of clinical oncology that report the results of novel and timely investigations. Reports on clinical trials are encouraged. Experimental studies will also be accepted if they have obvious relevance to clinical oncology. Membership in the Japan Society of Clinical Oncology is not a prerequisite for submission to the journal. Papers are received on the understanding that: their contents have not been published in whole or in part elsewhere; that they are subject to peer review by at least two referees and the Editors, and to editorial revision of the language and contents; and that the Editors are responsible for their acceptance, rejection, and order of publication.