Mitophagy’s impacts on cancer and neurodegenerative diseases: implications for future therapies

IF 40.4 1区 医学 Q1 HEMATOLOGY
Jason Huang, Vincent Truong Pham, Shaozi Fu, Gang Huang, Ya-Guang Liu, Lei Zheng
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引用次数: 0

Abstract

Substantial evidence supports an inverse relationship between cancer and neurodegenerative diseases (NDDs), but few studies investigate the biological mechanisms underlying this phenomenon. While previous explanations—such as inflammation, reactive oxygen species (ROS), genetic mutations, and cell death—remain significant, they ultimately converge on mitophagy. This review identifies mitophagy as a pivotal factor in the development of both cancer and NDDs, while also evaluating specific mechanisms and processes to clarify how mitophagy connects these opposing disease trajectories. By examining these factors, we aim to uncover the underlying mechanisms that explain the inverse relationship between cancer and NDDs, which will help develop therapeutic strategies that target common factors for both conditions.
线粒体自噬对癌症和神经退行性疾病的影响:对未来治疗的影响
大量证据支持癌症和神经退行性疾病(ndd)之间的反比关系,但很少有研究调查这一现象背后的生物学机制。虽然之前的解释——如炎症、活性氧(ROS)、基因突变和细胞死亡——仍然很重要,但它们最终都集中在线粒体自噬上。这篇综述确定了线粒体自噬是癌症和ndd发展的关键因素,同时也评估了特定的机制和过程,以阐明线粒体自噬如何将这些相反的疾病轨迹联系起来。通过检查这些因素,我们的目标是揭示解释癌症和ndd之间反向关系的潜在机制,这将有助于制定针对这两种情况的共同因素的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
48.10
自引率
2.10%
发文量
169
审稿时长
6-12 weeks
期刊介绍: The Journal of Hematology & Oncology, an open-access journal, publishes high-quality research covering all aspects of hematology and oncology, including reviews and research highlights on "hot topics" by leading experts. Given the close relationship and rapid evolution of hematology and oncology, the journal aims to meet the demand for a dedicated platform for publishing discoveries from both fields. It serves as an international platform for sharing laboratory and clinical findings among laboratory scientists, physician scientists, hematologists, and oncologists in an open-access format. With a rapid turnaround time from submission to publication, the journal facilitates real-time sharing of knowledge and new successes.
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