Blood Flow Restriction Training in People With Parkinson Disease: A Mixed-Methods Feasibility Study.

IF 4.2 3区医学 Q2 CLINICAL NEUROLOGY

Journal of Neurologic Physical Therapy Pub Date : 2025-07-28 DOI:10.1097/NPT.0000000000000530

Mark M Mañago, Lauren Van Valkenburgh, Katie Boncella, Robert Will, Jeanne Feuerstein, Laura A Swink, Cory L Christiansen

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引用次数: 0

Abstract

Background and purpose: To determine the feasibility of low-load resistance blood flow restriction training (BFRT) in people with Parkinson disease (PD).

Methods: This prospective cohort, convergent parallel mixed-methods design investigated the feasibility of 8 weeks of low-load resistance BFRT in people with PD. Feasibility was determined by enrolling 20 participants, ≥80% retention and adherence, and no serious intervention-related adverse events. Semistructured interviews and questionnaires evaluated acceptability and satisfaction. Changes in muscle strength and thickness, mobility, physical activity, and patient-reported outcomes were also assessed.

Results: Sixteen of 20 participants (80%) were retained at the postintervention assessment (68.1 ± 8.6 years old, 44% Female), completing 88% of visits with no serious adverse events. Qualitative analysis identified 3 themes: satisfaction and acceptability, functional capacity changes, and program feedback. Most participants were satisfied (88%), and lack of satisfaction was primarily related to pressure intolerance and exercise specificity. There were improvements in knee extension and ankle plantarflexion strength (18-22%), 30-Second Sit to Stand (+2.2 reps), Timed Up and Go (-2.1 seconds), and 10-Meter Walk Test (0.12 m/s). The average daily step count decreased (-476 steps/day) and sedentary time increased (21 minutes/day). There were minimal changes in elbow extension strength, rectus femoris muscle thickness, Parkinson's Fatigue Scale, and Patient-Specific Functional Scale.

Discussion and conclusions: BFRT was feasible and safe in people with PD, with promising improvements in muscle strength and mobility, warranting a future efficacy study. Clinicians considering BFRT should carefully evaluate tolerance and make sure BFRT aligns with patient goals.

Video Abstract available for more insights from the authors (see the Video, Supplemental Digital Content available at: http://links.lww.com/JNPT/A539).

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帕金森病患者血流量限制训练：一项混合方法可行性研究

背景与目的：探讨低负荷阻力血流量限制训练（BFRT）在帕金森病（PD）患者中的可行性。方法：该前瞻性队列、收敛平行混合方法设计调查了PD患者进行8周低负荷抵抗性BFRT的可行性。通过纳入20名参与者，≥80%的保留和依从性，以及无严重的干预相关不良事件来确定可行性。半结构化访谈和问卷调查评估了可接受性和满意度。还评估了肌肉力量和厚度、活动性、体力活动和患者报告的结果的变化。结果：20名参与者中有16名（80%）在干预后评估中被保留（68.1±8.6岁，44%女性），完成88%的就诊，无严重不良事件。定性分析确定了3个主题：满意度和可接受性、功能能力变化和程序反馈。大多数参与者满意（88%），缺乏满意度主要与压力不耐受和运动特异性有关。在膝关节伸展和踝关节屈曲强度（18-22%）、30秒坐立（+2.2次）、计时起身和行走（-2.1秒）和10米步行测试（0.12米/秒）方面都有改善。平均每日步数减少（-476步/天），久坐时间增加（21分钟/天）。肘关节伸展强度、股直肌厚度、帕金森疲劳量表和患者特异性功能量表的变化很小。讨论和结论：BFRT在PD患者中是可行且安全的，有希望改善肌肉力量和活动能力，值得未来的疗效研究。考虑BFRT的临床医生应仔细评估耐受性，并确保BFRT符合患者的目标。视频摘要可获得作者的更多见解（参见视频，补充数字内容可在：http://links.lww.com/JNPT/A539）。

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来源期刊

Journal of Neurologic Physical Therapy CLINICAL NEUROLOGY-REHABILITATION

CiteScore

5.70

自引率

2.60%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Neurologic Physical Therapy (JNPT) is an indexed resource for dissemination of research-based evidence related to neurologic physical therapy intervention. High standards of quality are maintained through a rigorous, double-blinded, peer-review process and adherence to standards recommended by the International Committee of Medical Journal Editors. With an international editorial board made up of preeminent researchers and clinicians, JNPT publishes articles of global relevance for examination, evaluation, prognosis, intervention, and outcomes for individuals with movement deficits due to neurologic conditions. Through systematic reviews, research articles, case studies, and clinical perspectives, JNPT promotes the integration of evidence into theory, education, research, and practice of neurologic physical therapy, spanning the continuum from pathophysiology to societal participation.