Impact of challenging-to-treat areas on quality of life and mental health among plaque psoriasis patients from Sabah, Malaysia.

Q3 Medicine

Medical Journal of Malaysia Pub Date : 2025-07-01

E Y L Ong, S Y M Voo

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引用次数: 0

Abstract

Introduction: Patients with psoriasis with involvement of challenging-to-treat-areas often have higher disease burden. We studied the impact of the challenging-to-treat areas namely scalp, face, nail, palms, soles and genitalia on the quality of life and mental health of psoriatic patients.

Materials and methods: We conducted a cross-sectional study involving 120 patients aged 18 years and above with plaque psoriasis. Those with challenging-to-treat-areas were compared to those without.

Results: The prevalence of challenging-to-treat-areas were scalp (35.8%), face (26.7%), nails (38.3%), palms (6.7%), soles (5.0%) and genitalia (15.0%). Psoriasis Area and Severity Index (PASI) was higher in patients with challenging-to-treat areas, with a median of 4.55 (IQR: 3.00, 7.80) compared to 1.80 (IQR: 0.60, 2.85) in those without (p < 0.001). Patients with these areas demonstrated a significantly higher Disease Life Quality Index (DLQI) scores compared to those without (mean ± SD: 5.13 ± 6.17 vs 11.02 ± 7.19; p < 0.001). Overall the prevalence of depression, anxiety and stress, scored using Depression, Anxiety and Stress Scale-21 Item (DASS-21), were 19.2%, 28.3% and 14.2% respectively with two thirds of patients had challenging-to-treat areas. Significantly more patients with challenging-to-treat-areas suffered from moderate to extremely severe depression (8.4% vs 5.0%, p = 0.034) and anxiety (33.4% vs 16.7%, p = 0.001). Patients with challenging-to-treat areas had higher mean itch Numeric Rating Scale (NRS) (4.28 ± 2.90) compared to those without (1.45 ± 1.58) (p < 0.001).

Conclusion: Patients with psoriasis with challenging-totreat- areas reported greater impairment in quality of life and higher risk of depression and anxiety.

本刊更多论文

挑战治疗地区对马来西亚沙巴斑块型银屑病患者生活质量和心理健康的影响

简介：银屑病患者累及难治性治疗区往往有较高的疾病负担。我们研究了头皮、面部、指甲、手掌、脚底和生殖器等难以治疗的区域对银屑病患者生活质量和心理健康的影响。材料和方法：我们对120例年龄在18岁及以上的斑块型银屑病患者进行了横断面研究。研究人员将那些有“治疗挑战区”的人与没有“治疗挑战区”的人进行了比较。结果：挑战治疗部位为头皮（35.8%）、面部（26.7%）、指甲（38.3%）、手掌（6.7%）、脚底（5.0%）和生殖器（15.0%）。有挑战治疗区患者的银屑病面积和严重程度指数（PASI）较高，中位值为4.55 (IQR: 3.00, 7.80)，而无挑战治疗区患者的中位值为1.80 (IQR: 0.60, 2.85) （p < 0.001）。有这些区域的患者的疾病生活质量指数（DLQI）评分明显高于无这些区域的患者(mean±SD: 5.13±6.17 vs 11.02±7.19；P < 0.001)。总体而言，使用抑郁、焦虑和压力量表21项（DASS-21）评分的抑郁、焦虑和压力患病率分别为19.2%、28.3%和14.2%，其中三分之二的患者存在挑战治疗领域。具有挑战治疗区域的患者中出现中度至极重度抑郁（8.4% vs 5.0%, p = 0.034）和焦虑（33.4% vs 16.7%, p = 0.001）的患者明显更多。有挑战治疗区患者的平均瘙痒数值评定量表（NRS）（4.28±2.90）高于无挑战治疗区患者（1.45±1.58）（p < 0.001）。结论：银屑病难治性区域患者生活质量受损更严重，抑郁和焦虑风险更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical Journal of Malaysia Medicine-Medicine (all)

CiteScore

1.20

自引率

0.00%

发文量

165

期刊介绍： Published since 1890 this journal originated as the Journal of the Straits Medical Association. With the formation of the Malaysian Medical Association (MMA), the Journal became the official organ, supervised by an editorial board. Some of the early Hon. Editors were Mr. H.M. McGladdery (1960 - 1964), Dr. A.A. Sandosham (1965 - 1977), Prof. Paul C.Y. Chen (1977 - 1987). It is a scientific journal, published quarterly and can be found in medical libraries in many parts of the world. The Journal also enjoys the status of being listed in the Index Medicus, the internationally accepted reference index of medical journals. The editorial columns often reflect the Association''s views and attitudes towards medical problems in the country. The MJM aims to be a peer reviewed scientific journal of the highest quality. We want to ensure that whatever data is published is true and any opinion expressed important to medical science. We believe being Malaysian is our unique niche; our priority will be for scientific knowledge about diseases found in Malaysia and for the practice of medicine in Malaysia. The MJM will archive knowledge about the changing pattern of human diseases and our endeavours to overcome them. It will also document how medicine develops as a profession in the nation. We will communicate and co-operate with other scientific journals in Malaysia. We seek articles that are of educational value to doctors. We will consider all unsolicited articles submitted to the journal and will commission distinguished Malaysians to write relevant review articles. We want to help doctors make better decisions and be good at judging the value of scientific data. We want to help doctors write better, to be articulate and precise.