Human T-lymphotropic virus-1 proviral load among patients on maintenance hemodialysis.

Q3 Medicine

Medical Journal of Malaysia Pub Date : 2025-07-01

Z S Al-Jubouri, S F Abdullah

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引用次数: 0

Abstract

Introduction: Human T-lymphotropic virus type 1(HTLV-1) is a complicated leukemogenic retrovirus, it is the first oncogenic virus discovered and identified as the leading cause of T-cell malignancy and HTLV related myelopathy with a long latency period. Transmission via infected blood products is one of the common routes of HTLV-1 infection, and hemodialysis patients are potentially more vulnerable to blood-borne viral infections such as HTLV. This study aimed to determine the factors associated with HTLV-1 proviral load among hemodialysis patients.

Materials and methods: A cross-sectional study of 130 patients undergoing hemodialysis was conducted between November 2023 and January 2024. After HTLV-1 RNA extraction, complementary DNA (cDNA) was synthesized. HTLV-1 pro-viral load (PVL) was quantified by real-time PCR (qRT-PCR).

Results: HTLV-proviral load was detected in 57 (43.84%) blood samples, with a mean ± standard deviation (SD) of 16.3×103 ± 5.4×104(copies/μL), including 34 (26.2%) males and 23 (17.7%) females. The highest percentage of infection (22.3%) was detected in the 40-59 age group and married patients (39.2%); however, a high viral load was observed in the 20-39 age group. Frequent blood transfusions associated with HTLV-1 infection were observed in 42 patients (32.3%). Myelopathy-related muscle spasms and paresthesia were significantly associated with the HTLV-1 viral load (p<0.05). A statistically significant relationship was observed between asymptomatic patients and high HTLV-1 proviral load (p=0.004).

Conclusion: These findings show that a significant number of dialysis patients were infected with HTLV-1. Therefore, hemodialysis patients should be frequently screened for HTLV-1 infections.

本刊更多论文

维持性血液透析患者的嗜t淋巴病毒-1前病毒载量。

人类嗜t淋巴病毒1型（HTLV-1）是一种复杂的致白血病逆转录病毒，是第一个发现并确定的致瘤病毒，是t细胞恶性肿瘤和HTLV相关脊髓病的主要病因，具有较长的潜伏期。通过受感染的血液制品传播是HTLV-1感染的常见途径之一，血液透析患者可能更容易受到HTLV等血源性病毒感染。本研究旨在确定血液透析患者HTLV-1前病毒载量的相关因素。材料与方法：对2023年11月至2024年1月期间接受血液透析治疗的130例患者进行横断面研究。HTLV-1 RNA提取后，合成互补DNA （cDNA）。实时荧光定量PCR （qRT-PCR）检测HTLV-1前病毒载量（PVL）。结果：57份血样中检出htlv前病毒载量（43.84%），平均±标准差（SD）为16.3×103±5.4×104（拷贝/μL），其中男性34份（26.2%），女性23份（17.7%）。40 ~ 59岁年龄组感染率最高（22.3%），已婚患者感染率最高（39.2%）；然而，在20-39岁年龄组中观察到高病毒载量。42例患者（32.3%）出现与HTLV-1感染相关的频繁输血。脊髓病相关的肌肉痉挛和感觉异常与HTLV-1病毒载量显著相关(结论：这些发现表明有相当数量的透析患者感染HTLV-1。因此，血液透析患者应经常筛查HTLV-1感染。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical Journal of Malaysia Medicine-Medicine (all)

CiteScore

1.20

自引率

0.00%

发文量

165

期刊介绍： Published since 1890 this journal originated as the Journal of the Straits Medical Association. With the formation of the Malaysian Medical Association (MMA), the Journal became the official organ, supervised by an editorial board. Some of the early Hon. Editors were Mr. H.M. McGladdery (1960 - 1964), Dr. A.A. Sandosham (1965 - 1977), Prof. Paul C.Y. Chen (1977 - 1987). It is a scientific journal, published quarterly and can be found in medical libraries in many parts of the world. The Journal also enjoys the status of being listed in the Index Medicus, the internationally accepted reference index of medical journals. The editorial columns often reflect the Association''s views and attitudes towards medical problems in the country. The MJM aims to be a peer reviewed scientific journal of the highest quality. We want to ensure that whatever data is published is true and any opinion expressed important to medical science. We believe being Malaysian is our unique niche; our priority will be for scientific knowledge about diseases found in Malaysia and for the practice of medicine in Malaysia. The MJM will archive knowledge about the changing pattern of human diseases and our endeavours to overcome them. It will also document how medicine develops as a profession in the nation. We will communicate and co-operate with other scientific journals in Malaysia. We seek articles that are of educational value to doctors. We will consider all unsolicited articles submitted to the journal and will commission distinguished Malaysians to write relevant review articles. We want to help doctors make better decisions and be good at judging the value of scientific data. We want to help doctors write better, to be articulate and precise.