VDAC2 brake release: unleashing inflammation via IFNγ.

IF 19.9 1区医学 Q1 PHARMACOLOGY & PHARMACY

Trends in pharmacological sciences Pub Date : 2025-07-29 DOI:10.1016/j.tips.2025.07.001

Swapneel J Patel, Zhijian J Chen

引用次数: 0

Abstract

Identification of therapeutic vulnerabilities in cancer remains a high priority for cancer research. A recent CRISPR/Cas9 screen identified that VDAC2 deletion in tumors enhanced their sensitivity to interferon-γ (IFNγ) through the release of mitochondrial DNA (mtDNA) and activation of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway. These data suggest that VDAC2 inhibition could enhance antitumor therapies.

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VDAC2刹车释放：通过IFNγ释放炎症。

确定癌症的治疗脆弱性仍然是癌症研究的重中之重。最近的一项CRISPR/Cas9筛选发现，肿瘤中的VDAC2缺失通过释放线粒体DNA （mtDNA）和激活环GMP-AMP合成酶(cGAS)-干扰素基因刺激因子（STING）途径增强了它们对干扰素-γ (IFNγ)的敏感性。这些数据表明，抑制VDAC2可以增强抗肿瘤治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in pharmacological sciences 医学-药学

CiteScore

23.90

自引率

0.70%

发文量

132

审稿时长

6-12 weeks

期刊介绍： Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research. The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics. Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles. Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.