{"title":"Role of Clot Formation and Plasminogen Activation in Lower Urinary Tract Pathologies.","authors":"Jonathan J Molina, Ana Lidia Flores-Mireles","doi":"10.1161/ATVBAHA.125.321600","DOIUrl":null,"url":null,"abstract":"<p><p>Hemostasis, a critical physiological process, is essential for stopping bleeding and initiating tissue repair after injury. It involves a tightly coordinated interplay between coagulation (blood clotting) and fibrinolysis (clot breakdown). Dysregulation of hemostasis can result in a wide range of diseases, such as infections, cancers, metabolic disorders, and neurodegenerative disorders. In the urinary tract, disruption of homeostasis and induction of hemostasis by diseases or foreign bodies (such as urinary catheters) can lead to various problems, such as infections, inflammation, and structural damage. Furthermore, hemostatic proteins have been associated with severe cancer progression. Thus, highlighting the roles of clot formation and plasminogen activation in urinary tract pathologies is important. This review details the pathogenesis of the urinary tract and urothelial carcinoma, as well as the roles of clot formation and plasminogen activation during disease onset and progression.</p>","PeriodicalId":8401,"journal":{"name":"Arteriosclerosis, Thrombosis, and Vascular Biology","volume":" ","pages":""},"PeriodicalIF":7.4000,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Arteriosclerosis, Thrombosis, and Vascular Biology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1161/ATVBAHA.125.321600","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"HEMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Hemostasis, a critical physiological process, is essential for stopping bleeding and initiating tissue repair after injury. It involves a tightly coordinated interplay between coagulation (blood clotting) and fibrinolysis (clot breakdown). Dysregulation of hemostasis can result in a wide range of diseases, such as infections, cancers, metabolic disorders, and neurodegenerative disorders. In the urinary tract, disruption of homeostasis and induction of hemostasis by diseases or foreign bodies (such as urinary catheters) can lead to various problems, such as infections, inflammation, and structural damage. Furthermore, hemostatic proteins have been associated with severe cancer progression. Thus, highlighting the roles of clot formation and plasminogen activation in urinary tract pathologies is important. This review details the pathogenesis of the urinary tract and urothelial carcinoma, as well as the roles of clot formation and plasminogen activation during disease onset and progression.
期刊介绍：
The journal "Arteriosclerosis, Thrombosis, and Vascular Biology" (ATVB) is a scientific publication that focuses on the fields of vascular biology, atherosclerosis, and thrombosis. It is a peer-reviewed journal that publishes original research articles, reviews, and other scholarly content related to these areas. The journal is published by the American Heart Association (AHA) and the American Stroke Association (ASA).
The journal was published bi-monthly until January 1992, after which it transitioned to a monthly publication schedule. The journal is aimed at a professional audience, including academic cardiologists, vascular biologists, physiologists, pharmacologists and hematologists.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
