Preliminary investigation on the association of dietary total antioxidant capacity, alternative healthy eating index, and dietary inflammatory index with intestinal microbiota in patients with diabetic nephropathy.
{"title":"Preliminary investigation on the association of dietary total antioxidant capacity, alternative healthy eating index, and dietary inflammatory index with intestinal microbiota in patients with diabetic nephropathy.","authors":"Fatemeh Zali, Solaleh Emamgholipour, Akram Vatannejad, Seyed Dawood Mousavi Nasab, Abdorrahim Absalan, Hanieh-Sadat Ejtahed, Ensieh Nasli-Esfahani, Nayebali Ahmadi, Seyed Davar Siadat, Parvin Pasalar, Farideh Razi, Fataneh Esmaeili","doi":"10.1007/s00592-025-02568-2","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Diabetic nephropathy (DN) is one of the most abundant microangiopathy complications among diabetic patients. Gut dysbiosis and the correlation with dietary factors in diabetic participants is undeniable. This study aims to evaluate the alteration of intestinal microbiota and its association with dietary indices, including dietary total antioxidant capacity (dTAC), dietary inflammatory index (DII), and alternative healthy eating index (AHEI) scores among healthy controls (HC) and diabetic participants with and without DN.</p><p><strong>Methods: </strong>The participants were categorized into type 2 diabetes mellitus (T2DM) group, DN group, and HC group. The intestinal microbiota was assessed using a quantitative real-time polymerase chain reaction (qPCR) method targeting the bacterial 16 S rRNA gene. Dietary data were obtained using a 168-item semi-quantitative food frequency questionnaire (FFQ).</p><p><strong>Results: </strong>A higher level of Escherichia, Prevotella, Facalibacterium, and Bacteroides was observed among the HC group than the T2DM and DN individuals. Higher AHEI was observed in the DN group than T2DM group. Lower DII was seen among the T2DM group compared to the HC and DN groups. dTAC index had no significant differences between the studied groups. Furthermore, in the HC group, dTAC showed a marginally significant positive correlation with Bacteroides. dTAC was negatively correlated with Lactobacillus in T2DM subjects. In the whole studied population, a marginally significant positive correlation between Prevotella and dTAC and DII was observed.</p><p><strong>Conclusions: </strong>Alterations in the intestinal microbiota were observed in participants suffering from T2DM and DN. Furthermore, some intestinal microbiota were associated with AHEI, DII, and dTAC dietary indices.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Diabetologica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00592-025-02568-2","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Diabetic nephropathy (DN) is one of the most abundant microangiopathy complications among diabetic patients. Gut dysbiosis and the correlation with dietary factors in diabetic participants is undeniable. This study aims to evaluate the alteration of intestinal microbiota and its association with dietary indices, including dietary total antioxidant capacity (dTAC), dietary inflammatory index (DII), and alternative healthy eating index (AHEI) scores among healthy controls (HC) and diabetic participants with and without DN.
Methods: The participants were categorized into type 2 diabetes mellitus (T2DM) group, DN group, and HC group. The intestinal microbiota was assessed using a quantitative real-time polymerase chain reaction (qPCR) method targeting the bacterial 16 S rRNA gene. Dietary data were obtained using a 168-item semi-quantitative food frequency questionnaire (FFQ).
Results: A higher level of Escherichia, Prevotella, Facalibacterium, and Bacteroides was observed among the HC group than the T2DM and DN individuals. Higher AHEI was observed in the DN group than T2DM group. Lower DII was seen among the T2DM group compared to the HC and DN groups. dTAC index had no significant differences between the studied groups. Furthermore, in the HC group, dTAC showed a marginally significant positive correlation with Bacteroides. dTAC was negatively correlated with Lactobacillus in T2DM subjects. In the whole studied population, a marginally significant positive correlation between Prevotella and dTAC and DII was observed.
Conclusions: Alterations in the intestinal microbiota were observed in participants suffering from T2DM and DN. Furthermore, some intestinal microbiota were associated with AHEI, DII, and dTAC dietary indices.
期刊介绍：
Acta Diabetologica is a journal that publishes reports of experimental and clinical research on diabetes mellitus and related metabolic diseases. Original contributions on biochemical, physiological, pathophysiological and clinical aspects of research on diabetes and metabolic diseases are welcome. Reports are published in the form of original articles, short communications and letters to the editor. Invited reviews and editorials are also published. A Methodology forum, which publishes contributions on methodological aspects of diabetes in vivo and in vitro, is also available. The Editor-in-chief will be pleased to consider articles describing new techniques (e.g., new transplantation methods, metabolic models), of innovative importance in the field of diabetes/metabolism. Finally, workshop reports are also welcome in Acta Diabetologica.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
