The Role of Extracellular Vesicles in Brain-Peripheral Communication Following Ischemic Stroke: Implications for Neural Repair and Regeneration

IF 4 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Neurochemistry Pub Date : 2025-07-31 DOI:10.1111/jnc.70155

Victória Linden de Rezende, Khiany Mathias, Maiara de Aguiar da Costa, Cinara Ludvig Gonçalves, Tatiana Barichello, Fabricia Petronilho

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Abstract

Ischemic stroke (IS) triggers complex neuroinflammatory and regenerative responses that extend beyond the brain. Extracellular vesicles (EVs), released by both central nervous system (CNS) and peripheral cells, have emerged as key mediators of communication between the brain and peripheral organs following IS. EVs are capable of transporting bioactive molecules across theblood-brain barrier (BBB), modulating systemic immune responses, influencing neuroinflammation, and promoting tissue repair. Additionally, peripheral EVs derived from immune cells, adipose tissue, bone, and the gut microbiota can impact brain recovery processes. This narrative review explores the dynamic and bidirectional roles of EVs in brain-periphery communication after stroke, highlighting their potential as diagnostic biomarkers and therapeutic agents. Despite promising preclinical findings, further research is needed to standardize experimental protocols, clarify the mechanisms of EV action, and advance their translation into clinical applications.

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缺血性卒中后细胞外囊泡在脑外周通讯中的作用：对神经修复和再生的影响

缺血性中风（IS）引发复杂的神经炎症和再生反应，并延伸到大脑之外。细胞外囊泡（EVs）由中枢神经系统（CNS）和外周细胞释放，是IS后大脑和外周器官之间通讯的关键介质。电动汽车能够通过血脑屏障（BBB）运输生物活性分子，调节全身免疫反应，影响神经炎症，促进组织修复。此外，来自免疫细胞、脂肪组织、骨骼和肠道微生物群的外周ev可以影响大脑的恢复过程。这篇叙述性综述探讨了脑电在脑卒中后脑外周通讯中的动态和双向作用，强调了它们作为诊断生物标志物和治疗药物的潜力。尽管有很好的临床前研究结果，但需要进一步的研究来规范实验方案，阐明EV的作用机制，并促进其转化为临床应用。

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来源期刊

Journal of Neurochemistry 医学-神经科学

CiteScore

9.30

自引率

2.10%

发文量

181

审稿时长

2.2 months

期刊介绍： Journal of Neurochemistry focuses on molecular, cellular and biochemical aspects of the nervous system, the pathogenesis of neurological disorders and the development of disease specific biomarkers. It is devoted to the prompt publication of original findings of the highest scientific priority and value that provide novel mechanistic insights, represent a clear advance over previous studies and have the potential to generate exciting future research.