Hypertension-related genes STOM, MEF2C promote proliferation and migration of clear cell renal cell carcinoma

Abstract

As one of the major subtypes of renal cell carcinoma (RCC), there is a distinct paucity of molecular studies exploring the effect of hypertension on the progression of clear cell renal cell carcinoma (ccRCC). In this study, we utilized multi-omics data, integrating it with AddModuleScore and Weighted Gene Co-Expression Network Analysis (WGCNA) algorithms. This approach enabled the identification of 30 hypertension-related genes (HRGs), of which 13 were found to be associated with ccRCC prognosis. The construction of a hypertension-related signature (HRS) utilizing 101 combinations of 10 machine learning algorithms was undertaken, with the objective of demonstrating a noteworthy forecasting capacity for the outcome of patients with ccRCC. In vitro, the co-culture of HUVEC with ccRCC cells has been shown to demonstrate that HUVEC can promote tumor proliferation and migration through the secretion of EGF, FGFB and VEGFA, which is regulated by STOM and MEF2C. Ultimately, through the utilisation of both Mendelian randomization analysis and molecular docking, that Perifosine, 7-Hydroxystaurosporine, and Mitoxantrone could represent efficacious treatment options for ccRCC patients by targeting PRAME. The findings provide novel evidence that hypertension influences the progression of ccRCC and offer new insights into the disease's pathophysiology.