Relationship between RAR and the risk of osteoarthritis: a comprehensive analysis based on NHANES data (1999–2018)

IF 1.5 Q3 ORTHOPEDICS

Journal of orthopaedics Pub Date : 2025-07-30 DOI:10.1016/j.jor.2025.07.028

Qifan Chen , Jiaxing Zeng , Hanhua Wu , Bufan Li , Yu-Nan Man , LuYang Zhong , Mao-Lin He , Shuizhong Cen

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引用次数: 0

Abstract

Background

Osteoarthritis (OA) is a prevalent disease characterized by the progressive loss of articular cartilage and chronic inflammation, contributing to an increasing epidemiological burden. While several risk factors have been identified, there remains a significant lack of reliable biomarkers for assessing OA risk. This study aims to investigate the association between the red blood cell distribution width to albumin ratio (RAR) and OA risk, as well as to evaluate its potential utility as a biomarker for OA risk assessment.

Methods

We utilized data from the National Health and Nutrition Examination Survey (NHANES) to include a total of 35,902 participants, among whom 4,285 were diagnosed with OA. A weighted logistic regression model was employed to assess the association between different quartiles of RAR and OA risk, adjusting for relevant confounding factors. Additionally, we applied a restricted cubic spline (RCS) model to explore the non-linear dose-response relationship between RAR and OA risk, and conducted subgroup analyses to further elucidate this association.

Results

RAR was significantly and positively associated with the risk of OA, with an odds ratio of 1.91 (95 % CI: 1.58–2.31, P = 5.31 × 10−10) for the highest quartile (Q4) in the weighted multivariate logistic regression model. This indicates a marked increase in OA risk with rising RAR levels. Furthermore, the relationship between RAR and OA was non-linear, and the effects of RAR exhibited significant heterogeneity across different populations.

Conclusion

The level of RAR is positively correlated with OA risk, suggesting its potential as a biomarker for OA risk assessment. However, since causality cannot be established, further prospective or longitudinal studies are necessary to validate its clinical relevance.

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RAR与骨关节炎风险的关系：基于NHANES数据的综合分析（1999-2018）

骨关节炎（OA）是一种以关节软骨进行性丧失和慢性炎症为特征的常见病，导致越来越多的流行病学负担。虽然已经确定了几个风险因素，但仍然缺乏可靠的生物标志物来评估OA风险。本研究旨在探讨红细胞分布宽度与白蛋白比（RAR）与OA风险之间的关系，并评估其作为OA风险评估的生物标志物的潜在效用。方法利用美国国家健康与营养调查（NHANES）的数据，共纳入35,902名参与者，其中4,285名被诊断为OA。采用加权logistic回归模型评估不同四分位数RAR与OA风险之间的相关性，并对相关混杂因素进行调整。此外，我们应用限制性三次样条（RCS）模型探讨了RAR与OA风险之间的非线性剂量-反应关系，并进行了亚组分析以进一步阐明这种关联。结果rar与OA风险显著正相关，在加权多因素logistic回归模型中，最高四分位数（Q4）的比值比为1.91 （95% CI: 1.58-2.31, P = 5.31 × 10−10）。这表明随着RAR水平的升高，OA风险显著增加。此外，RAR与OA呈非线性关系，且RAR效应在不同种群间表现出显著的异质性。结论RAR水平与OA风险呈正相关，可作为OA风险评估的生物标志物。然而，由于无法确定因果关系，因此需要进一步的前瞻性或纵向研究来验证其临床相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of orthopaedics ORTHOPEDICS-

CiteScore

3.50

自引率

6.70%

发文量

202

审稿时长

56 days

期刊介绍： Journal of Orthopaedics aims to be a leading journal in orthopaedics and contribute towards the improvement of quality of orthopedic health care. The journal publishes original research work and review articles related to different aspects of orthopaedics including Arthroplasty, Arthroscopy, Sports Medicine, Trauma, Spine and Spinal deformities, Pediatric orthopaedics, limb reconstruction procedures, hand surgery, and orthopaedic oncology. It also publishes articles on continuing education, health-related information, case reports and letters to the editor. It is requested to note that the journal has an international readership and all submissions should be aimed at specifying something about the setting in which the work was conducted. Authors must also provide any specific reasons for the research and also provide an elaborate description of the results.