Multi-omics profiling and molecular pathways in esophageal adenocarcinoma

IF 2.4 4区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Clinics and research in hepatology and gastroenterology Pub Date : 2025-07-28 DOI:10.1016/j.clinre.2025.102653

Qi Gao , Jing Xun , Bin Liu , Xiaolin Jiang , Yu Wang , Qi Zhang , Yu Wu

引用次数: 0

Abstract

Esophageal adenocarcinoma (EAC) is an aggressive malignancy with a rising incidence and poor prognosis. This review integrates current insights into the molecular features of EAC, focusing on the application of multi-omics approaches to unravel its genetic, transcriptomic, metabolic, and microenvironmental alterations. By identifying key biomarkers and therapeutic targets, we highlight the transformative potential of multi-omics in advancing precision medicine for EAC.

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食管腺癌的多组学分析和分子途径

食管腺癌（EAC）是一种发病率上升、预后差的侵袭性恶性肿瘤。这篇综述整合了目前对EAC分子特征的见解，重点是应用多组学方法来揭示其遗传，转录组学，代谢和微环境改变。通过确定关键的生物标志物和治疗靶点，我们强调了多组学在推进EAC精准医学方面的变革潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinics and research in hepatology and gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

4.30

自引率

3.70%

发文量

198

审稿时长

42 days

期刊介绍： Clinics and Research in Hepatology and Gastroenterology publishes high-quality original research papers in the field of hepatology and gastroenterology. The editors put the accent on rapid communication of new research and clinical developments and so called "hot topic" issues. Following a clear Editorial line, besides original articles and case reports, each issue features editorials, commentaries and reviews. The journal encourages research and discussion between all those involved in the specialty on an international level. All articles are peer reviewed by international experts, the articles in press are online and indexed in the international databases (Current Contents, Pubmed, Scopus, Science Direct). Clinics and Research in Hepatology and Gastroenterology is a subscription journal (with optional open access), which allows you to publish your research without any cost to you (unless you proactively chose the open access option). Your article will be available to all researchers around the globe whose institution has a subscription to the journal.