Awareness, and interest in personalized medicine: a cross-sectional survey study of health professionals.

Personalized medicine Pub Date : 2025-10-01 Epub Date: 2025-07-30 DOI:10.1080/17410541.2025.2538427

Ali Mostafaei, Aysan Rahmani, Kavous Shahsavarinia, Sepideh Harzand-Jadidi, Nooshin Milanchian, Fatemeh Rahmati, Hanieh Salehi-Pourmehr, Sakineh Hajebrahimi

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Abstract

Background: Personalized medicine (PM) is advancing disease prevention and treatment, but regulatory and clinical concerns persist, requiring evaluation of healthcare professionals' (HPs) knowledge and attitudes.

Methods: His study assessed PM awareness among HPs at Tabriz University of Medical Sciences, Iran. Participants from diverse clinical departments completed a survey covering PM definitions, benefits, ethical concerns, genetic testing knowledge, attitudes, and barriers. A literature review guided question development.

Results: Among 141 HPs (55.3% male, 44.7% female), only 27.7% reported sufficient PM knowledge, though 82.3% acknowledged genetic health influences. Those with adequate knowledge more often endorsed PM tools (92.3% vs. 68.6%, p = 0.01) but expressed greater concern about healthcare disparities (82.1% vs. 67.6%, p = 0.03). Key barriers included cost (17%) and ethical risks, with 72% fearing PM would widen economic gaps and 23.4% anticipating insurance discrimination. Females and married HPs were more concerned about discrimination (p = 0.039 and p = 0.038, respectively). Despite concerns, 80% of physicians supported genome-guided prescribing.

Conclusion: While HPs recognize PM's potential, limited awareness and ethical concerns hinder adoption. Addressing knowledge gaps and equity issues through education is crucial for PM integration in Iran.

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个性化医疗的意识和兴趣：卫生专业人员的横断面调查研究。

背景：个性化医疗（PM）正在推进疾病的预防和治疗，但监管和临床问题仍然存在，需要对卫生保健专业人员（hp）的知识和态度进行评估。方法：他的研究评估了伊朗大不里士医科大学hp的PM意识。来自不同临床科室的参与者完成了一项涵盖PM定义、益处、伦理问题、基因检测知识、态度和障碍的调查。文献综述引导问题发展。结果：141名hp（男性55.3%，女性44.7%）中，只有27.7%的人有足够的PM知识，尽管82.3%的人承认遗传健康影响。那些有足够知识的人更经常支持PM工具（92.3%对68.6%,p = 0.01），但对医疗保健差异表示更大的关注（82.1%对67.6%,p = 0.03）。主要障碍包括成本（17%）和道德风险，72%的人担心PM会扩大经济差距，23.4%的人担心保险歧视。女性和已婚hp更关心歧视（p = 0.039和p = 0.038）。尽管存在担忧，但80%的医生支持基因组指导处方。结论：虽然hp认识到PM的潜力，但有限的意识和伦理问题阻碍了采用PM。通过教育解决知识差距和公平问题对伊朗总理一体化至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Personalized medicine

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