Anahí Flores-Pérez , Marcos A. González-Olvera , Gustavo Chávez-Peña , Ana G. Gallardo-Hernández , Lizeth Torres
{"title":"Time-delay enhanced SIR model for COVID-19 waves in Mexico: Parameter estimation using evolutionary algorithms","authors":"Anahí Flores-Pérez , Marcos A. González-Olvera , Gustavo Chávez-Peña , Ana G. Gallardo-Hernández , Lizeth Torres","doi":"10.1016/j.jtbi.2025.112229","DOIUrl":null,"url":null,"abstract":"<div><div>In this work, we analyze the progression of COVID-19 across six distinct epidemic waves in Mexico using a time-delay SIR model, focusing specifically on whether the inclusion of incubation and recovery delays into the classical SIR framework enhances the model’s ability to capture the complex dynamics observed in epidemic data. To achieve robust and reliable estimation of both model parameters and time delays despite the inherent uncertainties present in pandemic data, we employ Particle Swarm Optimization (PSO) and Genetic Algorithms (GA). The performance of these optimization methods is assessed by examining their effectiveness in accurately reconstructing parameters across varying data with noise and uncertainties. Our findings indicate that both PSO and GA yield robust parameter and time-delay estimations even under scenarios where data have uncertainties, highlighting the critical role that time delays play in realistically modeling epidemic dynamics. The obtained results provide valuable insights into COVID-19 transmission patterns in Mexico and demonstrate the practical advantages of evolutionary algorithms for epidemic model calibration.</div></div>","PeriodicalId":54763,"journal":{"name":"Journal of Theoretical Biology","volume":"613 ","pages":"Article 112229"},"PeriodicalIF":2.0000,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Theoretical Biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S002251932500195X","RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
In this work, we analyze the progression of COVID-19 across six distinct epidemic waves in Mexico using a time-delay SIR model, focusing specifically on whether the inclusion of incubation and recovery delays into the classical SIR framework enhances the model’s ability to capture the complex dynamics observed in epidemic data. To achieve robust and reliable estimation of both model parameters and time delays despite the inherent uncertainties present in pandemic data, we employ Particle Swarm Optimization (PSO) and Genetic Algorithms (GA). The performance of these optimization methods is assessed by examining their effectiveness in accurately reconstructing parameters across varying data with noise and uncertainties. Our findings indicate that both PSO and GA yield robust parameter and time-delay estimations even under scenarios where data have uncertainties, highlighting the critical role that time delays play in realistically modeling epidemic dynamics. The obtained results provide valuable insights into COVID-19 transmission patterns in Mexico and demonstrate the practical advantages of evolutionary algorithms for epidemic model calibration.
期刊介绍:
The Journal of Theoretical Biology is the leading forum for theoretical perspectives that give insight into biological processes. It covers a very wide range of topics and is of interest to biologists in many areas of research, including:
• Brain and Neuroscience
• Cancer Growth and Treatment
• Cell Biology
• Developmental Biology
• Ecology
• Evolution
• Immunology,
• Infectious and non-infectious Diseases,
• Mathematical, Computational, Biophysical and Statistical Modeling
• Microbiology, Molecular Biology, and Biochemistry
• Networks and Complex Systems
• Physiology
• Pharmacodynamics
• Animal Behavior and Game Theory
Acceptable papers are those that bear significant importance on the biology per se being presented, and not on the mathematical analysis. Papers that include some data or experimental material bearing on theory will be considered, including those that contain comparative study, statistical data analysis, mathematical proof, computer simulations, experiments, field observations, or even philosophical arguments, which are all methods to support or reject theoretical ideas. However, there should be a concerted effort to make papers intelligible to biologists in the chosen field.