B3GNT2, GPR35, PSMG1 Gene Polymorphisms Are Related With Susceptibility and Severity of Ankylosing Spondylitis in Chinese Han Population.

IF 1.6 4区医学 Q4 GENETICS & HEREDITY

Molecular Genetics & Genomic Medicine Pub Date : 2025-08-01 DOI:10.1002/mgg3.70125

Zijian Lian, Bin Zhao, Wei Luo, Jun Liu, Jing Wang, Wei Chai, Yan Wang, Songqing Ye, Xinlong Ma

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引用次数: 0

Abstract

Background: Latest research on ankylosing spondylitis (AS) indicates a link between the B3GNT2, PSMG1 genes and susceptibility to AS among western populations. However, the association of these three genes with AS in eastern populations remains insufficiently explored. It is necessary to replicate these studies in other populations. Consequently, we chose tagSNPs in these three genes in the Chinese Han population to be sequenced.

Purpose: We tried to find the SNP loci that are associated in both eastern and western populations through repeated experiments. Furthermore, our research extended to examining the link between these genes and the severity of AS. This study aimed to evaluate the association between the tagSNPs of B3GNT2 (rs10865331, rs6545925, rs467250), the rs4676410 SNP on GPR35, and the rs4816648 SNP of PSMG1 with AS susceptibility and disease activity in a Chinese Han population.

Method: We collected blood samples from 497 patients with AS and 498 control subjects and sequenced 5 tagSNPs in B3GNT2, 1 tagSNP in GPR35, and 6 tagSNPs in PSMG1.

Result: Within the five selected tagSNPs of B3GNT2, the rs10865331, rs6545925, and rs4672501 tagSNPs are associated with susceptibility to AS. Additionally, the rs4672501 SNP is not only associated with susceptibility to AS, but also with the severity of AS. For the first time, we find that the rs4676410 SNP on the GPR35 gene is associated with susceptibility to AS, but not associated with the severity of AS in the Chinese Han population. We find for the first time that the rs4816648 SNP of the PSMG1 gene is associated with both susceptibility and severity of ankylosing spondylitis.

Conclusion: B3GNT2 and PSMG1 genes are related to both susceptibility and severity of AS. The GPR35 gene is related to susceptibility to AS in the Chinese Han population, which corroborates the findings of research conducted in western populations.

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B3GNT2、GPR35、PSMG1基因多态性与中国汉族强直性脊柱炎易感性和严重程度相关

背景：对强直性脊柱炎（AS）的最新研究表明，在西方人群中，B3GNT2、PSMG1基因与AS易感性有关。然而，这三种基因在东部人群中与AS的关系仍未得到充分探讨。有必要在其他人群中重复这些研究。因此，我们在中国汉族人群中选择了这三个基因的标签snp进行测序。目的：我们试图通过重复实验找到与东西方人群相关的SNP位点。此外，我们的研究扩展到检查这些基因与AS严重程度之间的联系。本研究旨在评估中国汉族人群B3GNT2的标签SNP （rs10865331、rs6545925、rs467250）、GPR35上的rs4676410 SNP和PSMG1上的rs4816648 SNP与AS易感性和疾病活动性之间的关系。方法：采集497例AS患者和498例对照者的血液样本，对B3GNT2中5个标签snp、GPR35中1个标签snp和PSMG1中6个标签snp进行测序。结果：在B3GNT2的5个tagsnp中，rs10865331、rs6545925和rs4672501与AS易感性相关。此外，rs4672501 SNP不仅与AS易感性相关，而且与AS的严重程度有关。我们首次发现GPR35基因上的rs4676410 SNP与AS易感性相关，但与中国汉族人群AS的严重程度无关。我们首次发现PSMG1基因的rs4816648 SNP与强直性脊柱炎的易感性和严重程度相关。结论：B3GNT2和PSMG1基因与AS易感性和严重程度均相关。GPR35基因与中国汉族AS易感性有关，这证实了在西方人群中进行的研究结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Genetics & Genomic Medicine Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

4.20

自引率

0.00%

发文量

241

审稿时长

14 weeks

期刊介绍： Molecular Genetics & Genomic Medicine is a peer-reviewed journal for rapid dissemination of quality research related to the dynamically developing areas of human, molecular and medical genetics. The journal publishes original research articles covering findings in phenotypic, molecular, biological, and genomic aspects of genomic variation, inherited disorders and birth defects. The broad publishing spectrum of Molecular Genetics & Genomic Medicine includes rare and common disorders from diagnosis to treatment. Examples of appropriate articles include reports of novel disease genes, functional studies of genetic variants, in-depth genotype-phenotype studies, genomic analysis of inherited disorders, molecular diagnostic methods, medical bioinformatics, ethical, legal, and social implications (ELSI), and approaches to clinical diagnosis. Molecular Genetics & Genomic Medicine provides a scientific home for next generation sequencing studies of rare and common disorders, which will make research in this fascinating area easily and rapidly accessible to the scientific community. This will serve as the basis for translating next generation sequencing studies into individualized diagnostics and therapeutics, for day-to-day medical care. Molecular Genetics & Genomic Medicine publishes original research articles, reviews, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented.