Acoltremon: First Approval.

IF 14.4 1区医学 Q1 PHARMACOLOGY & PHARMACY

Drugs Pub Date : 2025-10-01 Epub Date: 2025-07-30 DOI:10.1007/s40265-025-02218-5

Arnold Lee

引用次数: 0

Abstract

Acoltremon (TRYPTYR^®) is a TRPM8 thermoreceptor agonist formulated as eye drops, which has been developed by Alcon for the treatment of dry eye disease. As an insufficient aqueous layer is linked to dry eye disease, the stimulation of tear production by acoltremon can relieve symptoms associated with dry eye disease. During phase III trials in patients with dry eye disease, acoltremon demonstrated increased tear production with a low treatment discontinuation rate. This article summarizes the milestones in the development of acoltremon leading to this first approval for the treatment of the signs and symptoms of dry eye disease.

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Acoltremon：第一次批准。

acoltreon （TRYPTYR®）是一种TRPM8热受体激动剂，配制为滴眼液，由爱尔康公司开发用于治疗干眼症。由于水层不足与干眼病有关，因此用acoltreon刺激泪液产生可以缓解与干眼病相关的症状。在干眼病患者的III期试验中，acoltreon显示泪液产生增加，停药率低。这篇文章总结了acoltreon发展的里程碑，导致这一首次批准用于治疗干眼病的体征和症状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drugs 医学-毒理学

CiteScore

22.70

自引率

0.90%

发文量

134

审稿时长

3-8 weeks

期刊介绍： Drugs is a journal that aims to enhance pharmacotherapy by publishing review and original research articles on key aspects of clinical pharmacology and therapeutics. The journal includes: Leading/current opinion articles providing an overview of contentious or emerging issues. Definitive reviews of drugs and drug classes, and their place in disease management. Therapy in Practice articles including recommendations for specific clinical situations. High-quality, well designed, original clinical research. Adis Drug Evaluations reviewing the properties and place in therapy of both newer and established drugs. AdisInsight Reports summarising development at first global approval. Moreover, the journal offers additional digital features such as animated abstracts, video abstracts, instructional videos, and podcasts to increase visibility and educational value. Plain language summaries accompany articles to assist readers with some knowledge of the field in understanding important medical advances.