A glossary of signs and symptoms of giant cell arteritis.

IF 20.6 1区 医学 Q1 RHEUMATOLOGY
Medha L Soowamber, Milena Bond, Zahi Touma, Carol Langford, Catalina Sanchez-Alvarez, Andy Abril, Sibel Zehra Aydin, Frank Buttgereit, Dario Camellino, Maria C Cid, Peter C Grayson, Bernhard Hellmich, William Lichliter, Tanaz A Kermani, Nader A Khalidi, Sarah L Mackie, Eric L Matteson, Mehrdad Maz, Peter A Merkel, Paul A Monach, Lorna Neill, Cristina Ponte, Carlo Salvarani, Wolfgang A Schmidt, Peter M Villiger, Kenneth J Warrington, Madeline Whitlock, Sofia Ramiro, Christian Dejaco
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Abstract

Objectives: This study seeks to create consensus-based definitions of signs and symptoms of giant cell arteritis (GCA) for use by health care professionals, primarily in research settings.

Methods: Core definitions of signs and symptoms of GCA were extracted from 11 randomised controlled trials of GCA previously reviewed in a systematic literature review conducted in the context of the development of response criteria for GCA. This information was supplemented by definitions from other sources, such as rheumatology textbooks. A 2-round Delphi was performed within an international task force (32 members from 11 countries). The first round aimed to obtain consensus on the descriptive terms defining each sign or symptom, and round 2 rated the importance of these terms. Based on the Delphi study method, preliminary definitions were developed. In 4 online meetings, results of the Delphi were reviewed, and a consensus was achieved on final definitions.

Results: Twenty-nine signs and symptoms of GCA were reviewed. Six signs or symptoms of GCA had previously been defined in the literature. A high level of agreement was reached on the definition of 23 signs and symptoms with the following 12 considered characteristic of GCA: headache, temporal artery abnormalities, scalp tenderness, scalp necrosis, jaw claudication, tongue claudication, tongue necrosis, amaurosis fugax, permanent vision loss, fever, limb claudication, and blood pressure inequality.

Conclusions: A glossary of definitions for 23 signs and symptoms of GCA was developed through a consensus process involving international experts.

巨细胞动脉炎的体征和症状词汇表。
目的:本研究旨在建立基于共识的巨细胞动脉炎(GCA)体征和症状的定义,以供卫生保健专业人员主要在研究环境中使用。方法:从11项随机对照试验中提取GCA体征和症状的核心定义,这些随机对照试验之前在制定GCA反应标准的背景下进行了系统文献综述。这一信息还得到了风湿病学教科书等其他来源的定义的补充。在一个国际工作队(来自11个国家的32名成员)中进行了2轮德尔菲。第一轮旨在就定义每个体征或症状的描述性术语达成共识,第二轮评估这些术语的重要性。基于德尔菲研究方法,制定了初步的定义。在4次在线会议中,对德尔菲的结果进行了审查,并就最终定义达成了共识。结果:回顾了29例GCA的体征和症状。GCA的六个体征或症状先前在文献中被定义。对23个体征和症状的定义达成了高度一致,其中以下12个被认为是GCA的特征:头痛、颞动脉异常、头皮压痛、头皮坏死、下颌跛行、舌跛行、舌坏死、烟性黑朦、永久性视力丧失、发热、肢体跛行和血压不均匀。结论:通过涉及国际专家的共识进程,制定了23种GCA体征和症状的定义术语表。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases 医学-风湿病学
CiteScore
35.00
自引率
9.90%
发文量
3728
审稿时长
1.4 months
期刊介绍: Annals of the Rheumatic Diseases (ARD) is an international peer-reviewed journal covering all aspects of rheumatology, which includes the full spectrum of musculoskeletal conditions, arthritic disease, and connective tissue disorders. ARD publishes basic, clinical, and translational scientific research, including the most important recommendations for the management of various conditions.
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