Time in Tight Range (TITR) stratified by Time Below Range (TBR) in a cohort of patients with type 1 Diabetes Mellitus and Multiple Daily Injections. A real-life study.

IF 2.9 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Acta Diabetologica Pub Date : 2025-07-30 DOI:10.1007/s00592-025-02563-7

Sandra Herranz-Antolín, Sofía Ramos-Garrido, Verónica Esteban-Monge, Clara Coton-Batres, María Covadonga López-Virgos, Silvia Lallena-Pérez, Miguel Torralba

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Abstract

Objetive: To analyze the Time in Tight Range (TITR) (70-140 mg/dL) and assess their possible differences according to Time Below Range (TBR) in a cohort of type 1 diabetes mellitus people with Múltiple Daily Injections.

Patients and methods: 355 adult users of Continuous Glucose Monitoring (CGM) with at least a HbA1c during the period October 1, 2023-October 1, 2024, and glucose data in the 90 days prior were included.

Results: Age 46.9 years (SD 13.6); 57.2% male; time of evolution 21.6 years (SD 12.6). Mean TITR was 38.4% (SD 14.6) and 20.3% had a TITR ≥ 50%. The correlation TITR-TIR was strong (β = 0.83; CI 95% 0.8-0.87; R [2] Adjusted 0.89; p < 0.001) and varied according to TBR [TBR < 4% group (β = 0.81; CI 95% 0.78 to 0.85; R [2] Adjusted 0.9; p < 0.001) vs. TBR ≥ 4% (β = 0.9; CI 95% 0.86 to 0.94; R [2] Adjusted 0.93; p < 0.001)]. The variables independently associated with TITR in patient with TBR < 4% were HbA1c (β = -9.58; CI 95% -10.88 to -8.29; p < 0.001) and Coefficient of Variation (CV) (β = -0.38; CI 95% -0.66 to -0.11; p = 0.007). However, in those with TBR ≥ 4% were male gender (β = 2.86; CI 95% 0.26 to 5.45; p = 0.031), HbA1c (β = -7.53; CI 95% -9.1 to -5.96; p < 0.001) and CV (β = -0.69; CI 95% -1.01 to -0.37; p < 0.001).

Conclusions: The correlation between TITR and TIR and the factors that were independently associated with TITR differ depending on the TBR.

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在每日多次注射的1型糖尿病患者队列中，紧密范围时间（TITR）按低于范围时间（TBR）分层。一个真实的研究。

目的：分析1型糖尿病患者每日注射Múltiple的紧密范围时间（TITR）（70-140 mg/dL），并根据时间范围以下（TBR）评估其可能的差异。患者和方法：在2023年10月1日至2024年10月1日期间，355名HbA1c≥的成人连续血糖监测（CGM）使用者，并包括前90天的血糖数据。结果：年龄46.9岁（SD 13.6）；男性57.2%;演化时间21.6年（SD 12.6）。平均TITR为38.4% (SD 14.6)， 20.3%的患者TITR≥50%。tir - tir相关性强(β = 0.83；Ci 95% 0.8-0.87；R[2]调整0.89；p结论：TITR与TIR的相关性以及与TITR独立相关的因素因TBR而异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Diabetologica 医学-内分泌学与代谢

CiteScore

7.30

自引率

2.60%

发文量

180

审稿时长

2 months

期刊介绍： Acta Diabetologica is a journal that publishes reports of experimental and clinical research on diabetes mellitus and related metabolic diseases. Original contributions on biochemical, physiological, pathophysiological and clinical aspects of research on diabetes and metabolic diseases are welcome. Reports are published in the form of original articles, short communications and letters to the editor. Invited reviews and editorials are also published. A Methodology forum, which publishes contributions on methodological aspects of diabetes in vivo and in vitro, is also available. The Editor-in-chief will be pleased to consider articles describing new techniques (e.g., new transplantation methods, metabolic models), of innovative importance in the field of diabetes/metabolism. Finally, workshop reports are also welcome in Acta Diabetologica.