Acquisition of FGFR1 and NSD3 Amplifications During the Transformation of EGFR-Mutated Lung Adenocarcinoma into Squamous Cell Carcinoma: A Case Report

IF 3.5 Q2 ONCOLOGY

JTO Clinical and Research Reports Pub Date : 2025-06-13 DOI:10.1016/j.jtocrr.2025.100862

Naoki Fukunaga MD , Hideki Terai MD, PhD , Rui Nomura MD , Yutaka Kurebayashi MD, PhD , Kohei Nakamura MD, PhD , Ryutaro Kawano MD , Kohei Shigeta MD, PhD , Koji Okabayashi MD , Katsuhito Kinoshita MD , Akihiko Ogata MD , Lisa Shigematsu MD , Fumimaro Ito MD , Hatsuyo Takaoka MD , Takahiro Fukushima MD , Shigenari Nukaga MD, PhD , Keiko Ohgino MD, PhD , Hiroyuki Yasuda MD, PhD , Hiroshi Nishihara MD, PhD , Yuko Kitagawa MD, PhD , Koichi Fukunaga MD, PhD

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Abstract

Histologic transformation from adenocarcinoma to SCLC is a recognized mechanism of resistance in lung cancer. However, the transformation into squamous cell carcinoma is less common, and the associated genomic alterations remain unclear. Here, we present a case of lung adenocarcinoma harboring an EGFR (EGFR) mutation that transformed into squamous cell carcinoma. Although EGFR L858R mutation was detected throughout the transformation, genomic analyses were performed during the disease course, revealing the amplification of FGFR1 and NSD3, which have recently been proposed as potential driver oncogenes in lung squamous cell carcinoma. This case report highlights the genomic alterations observed in repeatedly biopsied specimens, along with a review of the relevant literature.

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egfr突变的肺腺癌向鳞状细胞癌转化过程中获得FGFR1和NSD3扩增：1例报告

从腺癌到小细胞肺癌的组织学转化是公认的肺癌耐药机制。然而，转化为鳞状细胞癌并不常见，相关的基因组改变尚不清楚。在此，我们报告一例肺腺癌携带EGFR （EGFR）突变转化为鳞状细胞癌。尽管在整个转化过程中检测到EGFR L858R突变，但在疾病过程中进行了基因组分析，揭示了FGFR1和NSD3的扩增，这两种基因最近被认为是肺鳞状细胞癌的潜在驱动癌基因。本病例报告强调了反复活检标本中观察到的基因组改变，并对相关文献进行了回顾。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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