Association between smoking status and suicide mortality in patients with type 2 diabetes: A nationwide population-based cohort study

IF 4.7 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Chaiho Jeong , Bongseong Kim , Dae Jong Oh , Tae-Seo Sohn , Kyungdo Han , Hyuk-Sang Kwon
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引用次数: 0

Abstract

Background

Patients with type 2 diabetes (T2D) are at greater risk of suicide due to stresses associated with disease management. Smoking adds to this burden. However, its association with suicide mortality in this population remains unclear. This study aimed to evaluate the relationship between smoking and suicide mortality in this high-risk group.

Methods

This cohort study utilized the Korean National Health Insurance Service (NHIS) database. A total of 2,524,769 participants aged ≥ 20 years with T2D who underwent national health examinations in 2015–2016 were included. Participants were followed until suicide death or the end of the study period.

Results

Over 5.8 years mean follow-up, 5,578 individuals died by suicide. Risk of suicide mortality was significantly higher—adjusted hazard ratio [95 % confidence interval]—in current smokers compared to never-smokers: 1.55 [1.44;1.67]. A dose–response pattern was observed among current smokers: 1.41 [1.22;1.63] for light smokers (<10 cigarettes/day) and 1.66 [1.52;1.81] for heavy smokers (≥20/day). In ex-smokers, only those with a smoking history of ≥ 30 years exhibited an elevated risk: 1.12 [1.02;1.24]. The association was particularly strong in women: 2.97 [2.39;3.69]; and individuals aged <65 years: 1.76 [1.61;1.92].

Conclusions

Current smoking was significantly associated with increased suicide mortality in patients with T2D, particularly among heavy smokers, women and those younger than 65 years. Long-term smoking history was also associated with elevated risk among ex-smokers.

Abstract Image

吸烟状况与2型糖尿病患者自杀死亡率之间的关系:一项基于全国人群的队列研究
背景:2型糖尿病(T2D)患者由于与疾病管理相关的压力而有更高的自杀风险。吸烟加重了这种负担。然而,其与该人群自杀死亡率的关系尚不清楚。本研究旨在评估吸烟与这一高危人群自杀死亡率之间的关系。方法:本队列研究利用韩国国民健康保险服务(NHIS)数据库。共纳入2015-2016年接受全国健康检查的年龄≥20岁T2D患者2,524,769例。参与者被跟踪到自杀死亡或研究期结束。结果:在5.8年的平均随访中,5578人死于自杀。与不吸烟者相比,当前吸烟者自杀死亡率的调整后危险比[95%置信区间]显著更高:1.55[1.44;1.67]。在当前吸烟者中观察到剂量-反应模式:轻度吸烟者为1.41[1.22;1.63](结论:当前吸烟与T2D患者自杀死亡率增加显著相关,特别是在重度吸烟者、女性和65岁以下的人群中。长期吸烟史也与戒烟者的风险增加有关。
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来源期刊
Diabetes & metabolism
Diabetes & metabolism 医学-内分泌学与代谢
CiteScore
12.00
自引率
4.20%
发文量
86
审稿时长
13 days
期刊介绍: A high quality scientific journal with an international readership Official publication of the SFD, Diabetes & Metabolism, publishes high-quality papers by leading teams, forming a close link between hospital and research units. Diabetes & Metabolism is published in English language and is indexed in all major databases with its impact factor constantly progressing. Diabetes & Metabolism contains original articles, short reports and comprehensive reviews.
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