Quantitative magnetic resonance imaging parameters of lumbar paraspinal muscles and their relationship to function and ageing in healthy subjects.

IF 2.3 2区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Viktoria Kokosova, Peter Krkoska, Daniela Vlazna, Marek Dostal, Petra Ovesna, Katerina Matulova, Blanka Adamova
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Abstract

Muscle ageing involves structural and functional changes of muscles, mainly their replacement by fatty and fibrous tissue accompanied by the loss of muscle function. Quantitative magnetic resonance imaging (qMRI) methods have potential to provide biomarkers of degenerative changes in muscles with ageing. To assess the relationship between qMRI parameters of lumbar paraspinal muscles (LPMs) and their function and evolution with ageing in healthy subjects, 90 volunteers underwent MRI of lumbar spine and LPM utilising a 6-point Dixon gradient echo sequence. Using manual muscle segmentation, fat fraction (FF) and functional muscle volume (FMV) were calculated for LPM, with the psoas muscle (PS) as a control muscle. Functional parameters of LPM (strength and endurance) were assessed. Based on our data analysis, both FF and FMV of LPM correlate significantly with maximal isometric lumbar extensor muscle strength, but not with endurance. With ageing, FF of LPM increases by 34% per decade, while FF of PS increases by 17% per decade. This difference between LPM and the PS in the rate of FF increase is significant. FMV evinces a decreasing trend in both LPM and PS. However, only FMV of PS decreases significantly by 7% per decade. Our cross-sectional study shows a significant correlation between qMRI parameters of LPM and their strength. FF appears to be a biomarker of muscle ageing with different ageing patterns of distinct muscle groups: LPM and PS.

健康受试者腰椎棘旁肌的定量磁共振成像参数及其与功能和衰老的关系。
肌肉老化涉及肌肉结构和功能的改变,主要是脂肪和纤维组织取代肌肉,同时伴有肌肉功能的丧失。定量磁共振成像(qMRI)方法有可能提供随年龄增长的肌肉退行性变化的生物标志物。为了评估健康受试者腰椎棘旁肌(LPM)的qMRI参数与其功能和随年龄变化的关系,90名志愿者使用6点Dixon梯度回声序列对腰椎和LPM进行了MRI检查。采用人工肌肉分割法,以腰肌(PS)为对照,计算脂肪分数(FF)和功能肌肉体积(FMV)。评估LPM的功能参数(强度和耐力)。根据我们的数据分析,LPM的FF和FMV与最大等距腰伸肌力量显著相关,但与耐力无关。随着老龄化,LPM的FF每10年增长34%,而PS的FF每10年增长17%。LPM和PS在FF增加速率上的差异是显著的。FMV在LPM和PS中均呈下降趋势,但只有PS的FMV每10年显著下降7%。我们的横断面研究显示LPM的qMRI参数与其强度之间存在显著相关性。FF似乎是肌肉衰老的生物标志物,不同肌肉群的衰老模式不同:LPM和PS。
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来源期刊
Quantitative Imaging in Medicine and Surgery
Quantitative Imaging in Medicine and Surgery Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
4.20
自引率
17.90%
发文量
252
期刊介绍: Information not localized
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