Effect of Proton Pump Inhibitor on Quality of Life of Patients with Laryngopharyngeal Reflux.

IF 0.4 Q4 SURGERY

Indian Journal of Otolaryngology and Head and Neck Surgery Pub Date : 2025-08-01 Epub Date: 2025-06-05 DOI:10.1007/s12070-025-05621-2

Kriti Bhatt, Rajeev Krishna Gupta, Anuja Bhargava, S M Faiz, Saurabh Srivastava, Eshani Dutta, Abdul Khalid

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引用次数: 0

Abstract

Introduction: Laryngopharyngeal reflux (LPR) is a common disease in the outpatient department of otolaryngology and is characterised by backflow of stomach contents into the pharynx and larynx resulting in significant negative impact on the quality of life of patients. The aim of study was to assess the effect of proton pump inhibitor (PPI) on quality of life in patients with LPR.

Method: 110 patients diagnosed with LPR were enrolled in study and prescribed omeprazole (20 mg) twice daily for 12 weeks. The Reflux Symptom Index (RSI), Reflux Finding Score (RFS) and LPR-health-related quality of life (HRQOL) were recorded for each patient at the initial visit and at 4th, 8th and 12th week follow-up visits.

Results: Mean RSI, RFS, HRQOL was 15.28 ± 1.19, 12.65 ± 1.16 and 77.77 ± 11.80 respectively at baseline. Significant improvement was observed in RSI and RFS scores after treatment. The HRQOL score also showed gradual improvement after PPI treatment.

Conclusion: PPI treatment brought about a significant improvement in signs, symptoms and quality of life of LPR patients.

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质子泵抑制剂对咽喉反流患者生活质量的影响。

喉咽反流（喉咽反流）是耳鼻喉科门诊的常见病，其特点是胃内容物反流到咽、喉，对患者的生活质量有显著的负面影响。本研究的目的是评估质子泵抑制剂（PPI）对LPR患者生活质量的影响。方法：选择110例诊断为LPR的患者，给予奥美拉唑（20 mg），每日2次，连续12周。记录每位患者首次访视及随访第4、8、12周时的反流症状指数（RSI）、反流发现评分（RFS）和lpr健康相关生活质量（HRQOL）。结果：RSI、RFS、HRQOL基线平均分别为15.28±1.19、12.65±1.16、77.77±11.80。治疗后RSI和RFS评分显著改善。PPI治疗后HRQOL评分也逐渐改善。结论：PPI治疗可显著改善LPR患者的体征、症状和生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian Journal of Otolaryngology and Head and Neck Surgery Medicine-Otorhinolaryngology

CiteScore

0.80

自引率

0.00%

发文量

226

审稿时长

6-12 weeks

期刊介绍： Indian Journal of Otolaryngology and Head & Neck Surgery was founded as Indian Journal of Otolaryngology in 1949 as a scientific Journal published by the Association of Otolaryngologists of India and was later rechristened as IJOHNS to incorporate the changes and progress. IJOHNS, undoubtedly one of the oldest Journals in India, is the official publication of the Association of Otolaryngologists of India and is about to publish it is 67th Volume in 2015. The Journal published quarterly accepts articles in general Oto-Rhino-Laryngology and various subspecialities such as Otology, Rhinology, Laryngology and Phonosurgery, Neurotology, Head and Neck Surgery etc. The Journal acts as a window to showcase and project the clinical and research work done by Otolaryngologists community in India and around the world. It is a continued source of useful clinical information with peer review by eminent Otolaryngologists of repute in their respective fields. The Journal accepts articles pertaining to clinical reports, Clinical studies, Research articles in basic and applied Otolaryngology, short Communications, Clinical records reporting unusual presentations or lesions and new surgical techniques. The journal acts as a catalyst and mirrors the Indian Otolaryngologist’s active interests and pursuits. The Journal also invites articles from senior and experienced authors on interesting topics in Otolaryngology and allied sciences from all over the world. The print version is distributed free to about 4000 members of Association of Otolaryngologists of India and the e-Journal shortly going to make its appearance on the Springer Board can be accessed by all the members. Association of Otolaryngologists of India and M/s Springer India group have come together to co-publish IJOHNS from January 2007 and this bondage is going to provide an impetus to the Journal in terms of international presence and global exposure.