Clinical Outcomes and Patterns of Failure After Intensity-Modulated Radiotherapy with Simultaneous Integrated Boost for Nasopharyngeal Carcinoma: A Single Institutional Review.
Isha B Shah, Vinay Shivhare, Satyajeet Rath, Niranjan K Dash, Ankita Parikh, U Suryanarayan Kunikullaya, T Arun, Akash Pandya
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引用次数: 0
Abstract
With conformal radiotherapy techniques, acute and late toxicities can be reduced because of significantly better dose conformity and reduced doses to normal tissue. With Intensity Modulated Radiation Therapy (IMRT) further dose escalation is possible. To evaluate clinical outcomes and patterns of failure after IMRT-SIB (Simultaneous integrated boost)/(Volumetric modulated arc therapy) VMAT technique in nasopharyngeal cancer patients. It is a retrospective analysis of 60 nasopharyngeal squamous cell carcinoma patients, treated with IMRT/VMAT radiotherapy and chemotherapy to primary and bilateral cervical nodes from March 2017 to December 2021. 60 patients received definitive treatment using IMRT-SIB. Patients were monitored during and after treatment for local and regional failure, distant metastasis, locoregional progression free and overall survival. Patient characteristics: median age 45; 75% male; 6.7% Stage I, 18.3% Stage II, 43.3% Stage III, 31.7% Stage IVA. The median follow up was 24.5 months (range 5.5-75.6). The 2-year local control, regional control, distant metastasis free, locoregional progression free and overall survival rates are 81.5, 82.9, 86.9, 77.7, 92.9%, respectively. 11 patients failed at the local site and 10 patients failed at regional sites, median time to failure was 12.2 months. The 5-year estimated regional control rate for N0 vs N + disease was 100% vs 74.2%(p-0.07). IMRT-SIB is a safe and acceptable treatment option for patients with carcinoma nasopharynx. The pattern of local failure within the target volume suggests locally advanced T stage disease may require a higher biologic dose to gross tumor.
Supplementary information: The online version contains supplementary material available at 10.1007/s12070-025-05539-9.
期刊介绍：
Indian Journal of Otolaryngology and Head & Neck Surgery was founded as Indian Journal of Otolaryngology in 1949 as a scientific Journal published by the Association of Otolaryngologists of India and was later rechristened as IJOHNS to incorporate the changes and progress.
IJOHNS, undoubtedly one of the oldest Journals in India, is the official publication of the Association of Otolaryngologists of India and is about to publish it is 67th Volume in 2015. The Journal published quarterly accepts articles in general Oto-Rhino-Laryngology and various subspecialities such as Otology, Rhinology, Laryngology and Phonosurgery, Neurotology, Head and Neck Surgery etc.
The Journal acts as a window to showcase and project the clinical and research work done by Otolaryngologists community in India and around the world. It is a continued source of useful clinical information with peer review by eminent Otolaryngologists of repute in their respective fields. The Journal accepts articles pertaining to clinical reports, Clinical studies, Research articles in basic and applied Otolaryngology, short Communications, Clinical records reporting unusual presentations or lesions and new surgical techniques. The journal acts as a catalyst and mirrors the Indian Otolaryngologist’s active interests and pursuits. The Journal also invites articles from senior and experienced authors on interesting topics in Otolaryngology and allied sciences from all over the world.
The print version is distributed free to about 4000 members of Association of Otolaryngologists of India and the e-Journal shortly going to make its appearance on the Springer Board can be accessed by all the members.
Association of Otolaryngologists of India and M/s Springer India group have come together to co-publish IJOHNS from January 2007 and this bondage is going to provide an impetus to the Journal in terms of international presence and global exposure.
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