A MeA Tac1 neural circuit mediates anxiety-like behaviors in mice.

IF 6.2 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

EMBO Reports Pub Date : 2025-09-01 Epub Date: 2025-07-28 DOI:10.1038/s44319-025-00528-z

Yao Wang, Jiu-Ye Qiao, Mei-Hui Yue, Xin-Yue Lv, Si-Ran Wang, Qian-Qian Yang, Han-Yun Kang, Hua-Li Yu, Xiao-Xiao He, Xiao-Juan Zhu, Zi-Xuan He

引用次数: 0

Abstract

Anxiety is an emotion characterized by worried thoughts and feelings of unease, often accompanied by physical symptoms such as sweating and dizziness. Unlike other negative emotions, the neural circuits underlying anxiety are not well understood. Here we report that Tachykinin Precursor 1 (Tac1)-expressing neurons in the medial amygdala (MeA) respond to the transition from high anxiety to low anxiety states. The MeATac1 neurons regulate anxiety-like behaviors in mice bidirectionally. We also show that GABAergic neurons in the ventral tegmental area (VTA)^GABA→MeA^Tac1→ventrolateral part of the ventromedial hypothalamic nucleus (VMHvl) circuit contribute to anxiety-like behavior in mice. Our findings reveal a circuit of Tac1 neurons in the MeA that mediates anxiety-like behaviors in mice.

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MeA - Tac1神经回路介导小鼠的焦虑样行为。

焦虑是一种以担心的想法和不安的感觉为特征的情绪，通常伴随着出汗和头晕等身体症状。与其他负面情绪不同，焦虑背后的神经回路还没有被很好地理解。在这里，我们报道了内侧杏仁核（MeA）中表达速激肽前体1 （Tac1）的神经元对从高焦虑状态到低焦虑状态的转变做出反应。MeATac1神经元双向调节小鼠的焦虑样行为。我们还发现腹侧被盖区（VTA）GABA→MeATac1→下丘脑腹内侧核（VMHvl）回路的腹外侧部分GABA能神经元参与小鼠的焦虑样行为。我们的发现揭示了MeA中Tac1神经元回路介导小鼠的焦虑样行为。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

EMBO Reports 生物-生化与分子生物学

CiteScore

11.20

自引率

1.30%

发文量

267

审稿时长

1 months

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