Targeted proteomic profiling of transcatheter edge-to-edge repair failure in patients with mitral regurgitation and heart failure.

IF 3.7 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Clinical Research in Cardiology Pub Date : 2025-07-29 DOI:10.1007/s00392-025-02712-6

Mattia Di Pasquale, Susana Ravassa, Matteo Pagnesi, Edoardo Pancaldi, Begoña López, Gorka San José, Cristina Gussago, Letizia Fiorentino, Alice Ravera, Lisa Serafini, Giuliano Chizzola, Carlo Mario Lombardi, Marco Metra, Arantxa González, Marianna Adamo

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引用次数: 0

Abstract

Aims: To assess the changes in circulating biomarkers concentrations after mitral valve transcatheter edge-to-edge repair (M-TEER) and their relationship with procedural success vs. failure in patients with severe mitral regurgitation (MR) and heart failure (HF).

Methods and results: Pre-procedural, post-intervention, and 30 days post-intervention plasma samples were analyzed for 266 different proteins using the Olink Proseek® Multiplex cardiovascular (CVD) II, CVD III, and inflammation panels, in patients with MR undergoing M-TEER. Multiple biomarkers showed a differential expression 30 days after M-TEER in patients with procedural failure vs. those with a successful evolution. The proteins upregulated in patients with procedural failure were functionally enriched in pathways related to immune regulation, inflammation, extracellular matrix organization, and cellular structures. After adjustment for confounding variables, increases in IL2RA, RAGE, IGFBP2, and COL1A1 values at 30 days post-intervention were associated with procedural failure. Changes in IGFBP2 and IL2RA values were also independently associated with pulmonary artery systolic pressure (PASP) increases after M-TEER.

Conclusion: In a cohort of patients with severe MR undergoing M-TEER, differences in circulating biomarkers concentrations related to inflammation and fibrosis were observed between patients with procedural success as compared to those with procedural failure. Biomarkers known to be associated with HF severity were over-expressed in patients with procedural failure, compared with those with procedural success, after M-TEER.

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二尖瓣反流和心力衰竭患者经导管边缘到边缘修复失败的靶向蛋白质组学分析。

目的：评估二尖瓣经导管边缘到边缘修复（M-TEER）后循环生物标志物浓度的变化及其与严重二尖瓣反流（MR）和心力衰竭（HF）患者手术成功与失败的关系。方法和结果：使用Olink Proseek®Multiplex心血管（CVD） II、CVD III和炎症面板，对接受M-TEER治疗的MR患者的手术前、干预后和干预后30天血浆样本进行266种不同蛋白质的分析。多种生物标志物显示M-TEER在程序失败患者与进化成功患者中30天后的差异表达。程序性失败患者中上调的蛋白质在与免疫调节、炎症、细胞外基质组织和细胞结构相关的途径中功能丰富。在调整混杂变量后，干预后30天IL2RA、RAGE、IGFBP2和COL1A1值的升高与程序性失败有关。IGFBP2和IL2RA值的变化也与M-TEER后肺动脉收缩压（PASP）升高独立相关。结论：在一组接受M-TEER治疗的严重MR患者中，观察到手术成功患者与手术失败患者之间与炎症和纤维化相关的循环生物标志物浓度的差异。在M-TEER后，与手术成功患者相比，手术失败患者中已知与HF严重程度相关的生物标志物过表达。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Research in Cardiology 医学-心血管系统

CiteScore

11.40

自引率

4.00%

发文量

140

审稿时长

4-8 weeks

期刊介绍： Clinical Research in Cardiology is an international journal for clinical cardiovascular research. It provides a forum for original and review articles as well as critical perspective articles. Articles are only accepted if they meet stringent scientific standards and have undergone peer review. The journal regularly receives articles from the field of clinical cardiology, angiology, as well as heart and vascular surgery. As the official journal of the German Cardiac Society, it gives a current and competent survey on the diagnosis and therapy of heart and vascular diseases.