Intranasal Terpene Treatment for Glioblastoma: the Neuro-Oncological Potential of Perillyl Alcohol

IF 3.8 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Neurochemical Research Pub Date : 2025-07-29 DOI:10.1007/s11064-025-04505-9

Emirhan Harbi, Erhan Yarar, Christopher E. Mason, Michael Aschner, Aytug Altundag

引用次数: 0

Abstract

Glioblastoma is the most aggressive and fatal primary brain tumor in adults, characterized by poor prognosis and limited treatment efficacy due to the impermeability of the blood-brain barrier (BBB) and its treatment-resistant nature. This review aims to evaluate the potential of intranasal terpene treatment (ITT) as a novel and non-invasive strategy to bypass the BBB and improve glioblastoma treatment outcomes. A review of recent preclinical and clinical studies on intranasally administered compounds (especially terpenes such as Perillyl alcohol (POH)) is presented in terms of their molecular mechanisms, bioavailability, and clinical effects in the central nervous system (CNS).

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鼻内萜烯治疗胶质母细胞瘤：紫苏醇的神经肿瘤学潜力。

胶质母细胞瘤是成人最具侵袭性和致死性的原发性脑肿瘤，由于血脑屏障（BBB）的不渗透性和治疗耐药性，其预后差，治疗效果有限。本综述旨在评估鼻内萜烯治疗（ITT）作为一种新的非侵入性策略来绕过血脑屏障并改善胶质母细胞瘤治疗结果的潜力。从分子机制、生物利用度和中枢神经系统（CNS）的临床作用等方面综述了近年来鼻内给药化合物（特别是萜烯，如紫苏醇（POH））的临床前和临床研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurochemical Research 医学-神经科学

CiteScore

7.70

自引率

2.30%

发文量

320

审稿时长

6 months

期刊介绍： Neurochemical Research is devoted to the rapid publication of studies that use neurochemical methodology in research on nervous system structure and function. The journal publishes original reports of experimental and clinical research results, perceptive reviews of significant problem areas in the neurosciences, brief comments of a methodological or interpretive nature, and research summaries conducted by leading scientists whose works are not readily available in English.