Racial and gender disparities in HPV vaccination: Implications for reducing head and neck cancer

IF 2.3 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Journal of the National Medical Association Pub Date : 2025-07-24 DOI:10.1016/j.jnma.2025.07.001

Kamdili Ogbutor , Elijah McMillan , Nurupa Ramkissoon , Rawan Elkomi , Da’Jhai Monroe , Samrawit Zinabu , Ahmed Ali , Huda Gasmelseed , Miriam Michael

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引用次数: 0

Abstract

Objective

Head and neck cancer caused by human papillomavirus (HPV) is a rare form of cancer that disproportionately impacts males more than their female counterparts (11.4 per 1000,000 compared to females 3.0 per 1000,000). Despite the introduction of vaccination for HPV there has still been an increase in incidence within the past 20 years. This study investigates disparities in HPV vaccination rate and head and neck cancer amongst gender and various racial groups within Washington, DC and Maryland.

Methods

Retrospective cross-sectional study of patients vaccinated for HPV from January 2014 to December 2020. Epic EMR Slicer Dicer tool analysis of 5.8 million de-identified patients via University of Maryland clinical database. Vaccination rates and head and neck cancer incidence were compared between respective gender and racial subgroups over a 6-year period.

Results

Females had significantly higher vaccination rates than males (58.1 % vs 41.9 %). Black females were the most vaccinated subgroup (27.6 %), while white males were the least vaccinated (16.8 %). Among vaccinated individuals, 0.13 % developed head and neck cancer. Of this percentage, there was a disproportionate representation of black females, accounting for 46.7 % of head and neck cancer cases despite having the highest vaccination rates.

Conclusion

Despite persistent vaccination efforts, we see an unexplained high incidence of head and neck cancer affecting black females. Targeted interventions are essential to improving health outcomes in this population.

Level of Evidence

查看原文本刊更多论文

HPV疫苗接种中的种族和性别差异：减少头颈癌的意义。

目的：由人乳头瘤病毒（HPV）引起的头颈癌是一种罕见的癌症，男性的发病率高于女性（每100万人中有11.4例，而女性为每100万人中有3.0例）。尽管引入了HPV疫苗接种，但在过去20年中发病率仍然有所增加。本研究调查了华盛顿特区和马里兰州不同性别和不同种族群体在HPV疫苗接种率和头颈癌方面的差异。方法：对2014年1月至2020年12月接种HPV疫苗的患者进行回顾性横断面研究。Epic EMR Slicer Dicer工具通过马里兰大学临床数据库分析了580万未识别的患者。在6年的时间里，比较了不同性别和种族亚组的疫苗接种率和头颈癌发病率。结果：女性接种率明显高于男性（58.1% % vs 41.9% %）。黑人女性是接种疫苗最多的亚组（27.6 %），而白人男性接种疫苗最少（16.8 %）。在接种疫苗的个体中，0.13 %发生头颈癌。在这一比例中，黑人女性的比例不成比例，尽管接种率最高，但她们占头颈癌病例的46.7% %。结论：尽管持续的疫苗接种努力，我们看到一个无法解释的头颈癌高发影响黑人女性。有针对性的干预措施对于改善这一人群的健康结果至关重要。证据等级：3；

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the National Medical Association 医学-医学：内科

CiteScore

4.80

自引率

3.00%

发文量

139

审稿时长

98 days

期刊介绍： Journal of the National Medical Association, the official journal of the National Medical Association, is a peer-reviewed publication whose purpose is to address medical care disparities of persons of African descent. The Journal of the National Medical Association is focused on specialized clinical research activities related to the health problems of African Americans and other minority groups. Special emphasis is placed on the application of medical science to improve the healthcare of underserved populations both in the United States and abroad. The Journal has the following objectives: (1) to expand the base of original peer-reviewed literature and the quality of that research on the topic of minority health; (2) to provide greater dissemination of this research; (3) to offer appropriate and timely recognition of the significant contributions of physicians who serve these populations; and (4) to promote engagement by member and non-member physicians in the overall goals and objectives of the National Medical Association.