Stem cell-derived extracellular vesicles: novel therapeutics for cerebral injury following cardiac arrest and potential mechanisms.

IF 6.2 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Xiaodan Zhang, Wenbin Zhang, Ziwei Chen, Ruojie Zhu, Yao Lin, Chenghao Wu, Jiefeng Xu, Guangju Zhou, Mao Zhang
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引用次数: 0

Abstract

Brain injury following cardiac arrest (CA) is a significant cause of mortality and poor prognosis in patients, and effective treatment strategies remain limited. Stem cell-derived extracellular vesicles (EVs), a novel cell-free therapeutic approach, have recently demonstrated significant potential in the field of brain injury repair. EVs, key mediators of stem cell paracrine and autocrine signaling, are enriched with bioactive molecules such as non-coding RNAs and proteins. These EVs have the capacity to traverse the bloodstream, reach injury sites, and modulate various biological processes, including neuronal survival, oxidative stress, inflammatory responses, blood-brain barrier integrity, and neurovascular regeneration.This review aims to provide a comprehensive overview of the research history, structural characteristics, and in vivo distribution and metabolism of stem cell-derived EVs. The review further explores their therapeutic potential and underlying mechanisms in post-CA brain injury, including the inhibition of neuronal apoptosis, alleviation of oxidative stress and inflammation, promotion of blood-brain barrier repair, and enhancement of neurovascular regeneration. Additionally, the review highlights emerging directions and challenges in the clinical application of stem cell-derived EVs, offering theoretical insights and perspectives for future research and translational development. The potential of stem cell-derived EVs as a breakthrough strategy for treating post-CA brain injury is underscored, offering renewed optimism for enhancing patient outcomes.

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干细胞来源的细胞外囊泡:心脏骤停后脑损伤的新疗法及其潜在机制。
心脏骤停(CA)后脑损伤是患者死亡和预后不良的重要原因,有效的治疗策略仍然有限。干细胞来源的细胞外囊泡(EVs)是一种新型的无细胞治疗方法,近年来在脑损伤修复领域显示出巨大的潜力。ev是干细胞旁分泌和自分泌信号的关键介质,富含非编码rna和蛋白质等生物活性分子。这些ev具有穿越血流、到达损伤部位并调节各种生物过程的能力,包括神经元存活、氧化应激、炎症反应、血脑屏障完整性和神经血管再生。本文旨在对干细胞源性ev的研究历史、结构特点、体内分布和代谢进行综述。本文将进一步探讨其在ca后脑损伤中的治疗潜力和潜在机制,包括抑制神经元凋亡,减轻氧化应激和炎症,促进血脑屏障修复,增强神经血管再生。此外,本文还强调了干细胞源性电动汽车临床应用的新兴方向和挑战,为未来的研究和转化开发提供了理论见解和观点。干细胞衍生的电动汽车作为治疗ca后脑损伤的突破性策略的潜力被强调,为提高患者的预后提供了新的乐观。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cell and Bioscience
Cell and Bioscience BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
10.70
自引率
0.00%
发文量
187
审稿时长
>12 weeks
期刊介绍: Cell and Bioscience, the official journal of the Society of Chinese Bioscientists in America, is an open access, peer-reviewed journal that encompasses all areas of life science research.
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