M H Wang, J Liu, S L Li, M Z Zheng, R Y Qu, M Xiang
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引用次数: 0
Abstract
Amphiregulin (AREG), a ligand of the epidermal growth factor receptor (EGFR), plays critical roles in immune homeostasis, cell proliferation, and tissue repair. Recent preclinical studies have shown that AREG is markedly upregulated in various fibrotic diseases and contributes to disease progression through distinct cell sources and signaling mechanisms. These advances highlight AREG as a fibrotic mediator with cellular and organ heterogeneity, suggesting that AREG-targeted therapies can be tailored with great specificity. This review synthesizes recent insights into AREG's expression dynamics, cellular sources, target cell types, and signaling mechanisms in fibrotic diseases, and presents a novel perspective on how this emerging knowledge may inform the development of selective, context-aware antifibrotic therapies.
期刊介绍：
Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research.
The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics.
Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles.
Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.
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