Emerging advances in intestinal models for in vitro preclinical research.

IF 3.3 3区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Precious Adedayo Adesina, Masato Ooka, Charlotte TeKrony, Menghang Xia
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引用次数: 0

Abstract

Traditional in vitro intestinal model systems frequently fail to accurately replicate human intestinal physiology for absorption, distribution, metabolism, excretion, and toxicity (ADMET) assessments. These limitations, coupled with the growing demand for faster drug discovery and high-throughput screening capabilities, have refined more physiologically relevant models. Recent advancements have led to the development of cell-based intestinal systems that better reflect in vivo conditions, ranging from monolayer and coculture models to complex three-dimensional (3-D) cell culture systems, microfluidic devices, and bioengineered models. This review provides a comprehensive overview of current progress, ongoing challenges, and future directions in developing and applying human in vitro intestinal models for chemical testing.

体外临床前研究肠道模型的新进展。
传统的体外肠道模型系统往往不能准确地复制人体肠道生理吸收、分布、代谢、排泄和毒性(ADMET)评估。这些限制,加上对更快的药物发现和高通量筛选能力的需求不断增长,已经完善了更多与生理相关的模型。最近的进展导致了基于细胞的肠道系统的发展,这些系统可以更好地反映体内条件,从单层和共培养模型到复杂的三维(3D)细胞培养系统、微流体装置和生物工程模型。本文综述了用于化学检测的人体体外肠道模型的研究进展、面临的挑战和未来发展方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
9.40
自引率
2.20%
发文量
104
审稿时长
1 months
期刊介绍: The American Journal of Physiology-Gastrointestinal and Liver Physiology publishes original articles pertaining to all aspects of research involving normal or abnormal function of the gastrointestinal tract, hepatobiliary system, and pancreas. Authors are encouraged to submit manuscripts dealing with growth and development, digestion, secretion, absorption, metabolism, and motility relative to these organs, as well as research reports dealing with immune and inflammatory processes and with neural, endocrine, and circulatory control mechanisms that affect these organs.
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