Aubrey J Emmi, Adrian S McFarland, Morgan M Grimes, Izaiah J Cole, Michael R Lawson
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引用次数: 0
Abstract
Eukaryotic translation is a highly regulated cellular process that not only directs the synthesis of proper polypeptides, but also helps to ensure the timely decay of faulty transcripts. In this review, we highlight the interdisciplinary approaches that have yielded key insights into mechanisms of the latter stages of eukaryotic translation and associated quality control pathways in the past decade. Synergies of these approaches are demonstrated through examination of recent discoveries regarding translation termination, ribosomal recycling, Nonsense-Mediated mRNA Decay, and No-Go Decay. In the long run, a detailed understanding of how translation concludes on normal and defective transcripts has the potential to inform the development of novel therapeutics for many hereditary diseases.
期刊介绍：
Journal of Molecular Biology (JMB) provides high quality, comprehensive and broad coverage in all areas of molecular biology. The journal publishes original scientific research papers that provide mechanistic and functional insights and report a significant advance to the field. The journal encourages the submission of multidisciplinary studies that use complementary experimental and computational approaches to address challenging biological questions.
Research areas include but are not limited to: Biomolecular interactions, signaling networks, systems biology; Cell cycle, cell growth, cell differentiation; Cell death, autophagy; Cell signaling and regulation; Chemical biology; Computational biology, in combination with experimental studies; DNA replication, repair, and recombination; Development, regenerative biology, mechanistic and functional studies of stem cells; Epigenetics, chromatin structure and function; Gene expression; Membrane processes, cell surface proteins and cell-cell interactions; Methodological advances, both experimental and theoretical, including databases; Microbiology, virology, and interactions with the host or environment; Microbiota mechanistic and functional studies; Nuclear organization; Post-translational modifications, proteomics; Processing and function of biologically important macromolecules and complexes; Molecular basis of disease; RNA processing, structure and functions of non-coding RNAs, transcription; Sorting, spatiotemporal organization, trafficking; Structural biology; Synthetic biology; Translation, protein folding, chaperones, protein degradation and quality control.
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