{"title":"Identity-By-Descent Mapping Using Multi-Individual IBD With Genome-Wide Multiple Testing Adjustment","authors":"Ruoyi Cai, Sharon R. Browning","doi":"10.1002/gepi.70015","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>We present an identity-by-descent mapping approach to test the association between genome-wide loci and complex traits. Our method evaluates whether levels of genetic similarities at specific genomic locations, captured by local relatedness matrices derived from multi-individual IBD sharing, are associated with phenotypic variation in complex traits. In addition, we propose an approach to adjust for multiple testing in genome-wide IBD mapping scans based on the correlation structure between test statistics across the genome. Through simulation studies, we demonstrate that our test has a well-controlled genome-wide type I error rate and superior power to detect rare and untyped variants compared to standard single-variant tests. We applied our method to systolic blood pressure data from White British individuals in the UK Biobank.</p>\n </div>","PeriodicalId":12710,"journal":{"name":"Genetic Epidemiology","volume":"49 6","pages":""},"PeriodicalIF":3.8000,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Genetic Epidemiology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/gepi.70015","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0
Abstract
We present an identity-by-descent mapping approach to test the association between genome-wide loci and complex traits. Our method evaluates whether levels of genetic similarities at specific genomic locations, captured by local relatedness matrices derived from multi-individual IBD sharing, are associated with phenotypic variation in complex traits. In addition, we propose an approach to adjust for multiple testing in genome-wide IBD mapping scans based on the correlation structure between test statistics across the genome. Through simulation studies, we demonstrate that our test has a well-controlled genome-wide type I error rate and superior power to detect rare and untyped variants compared to standard single-variant tests. We applied our method to systolic blood pressure data from White British individuals in the UK Biobank.
期刊介绍：
Genetic Epidemiology is a peer-reviewed journal for discussion of research on the genetic causes of the distribution of human traits in families and populations. Emphasis is placed on the relative contribution of genetic and environmental factors to human disease as revealed by genetic, epidemiological, and biologic investigations.
Genetic Epidemiology primarily publishes papers in statistical genetics, a research field that is primarily concerned with development of statistical, bioinformatical, and computational models for analyzing genetic data. Incorporation of underlying biology and population genetics into conceptual models is favored. The Journal seeks original articles comprising either applied research or innovative statistical, mathematical, computational, or genomic methodologies that advance studies in genetic epidemiology. Other types of reports are encouraged, such as letters to the editor, topic reviews, and perspectives from other fields of research that will likely enrich the field of genetic epidemiology.
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