The Association Between Autoimmune Rheumatic Diseases and Depression: A Two-Sample Bidirectional Mendelian Randomization.

IF 2.4 4区医学 Q2 PSYCHIATRY

Psychiatry-Interpersonal and Biological Processes Pub Date : 2025-07-24 DOI:10.1080/00332747.2025.2528526

Huiying Wang, Youqing Wang, Yujia Xu

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引用次数: 0

Abstract

Background: Although prior observational studies have indicated an association between depression and autoimmune rheumatic diseases (ARDs), the underlying causal relationship remains unclear.

Methods: A two-sample bidirectional Mendelian randomization (MR) study was conducted to explore the causal link between depression and ARDs. Genetic data for both depression and ARDs were obtained from publicly available genetic datasets. Instrumental variables were chosen as independent single-nucleotide polymorphisms (SNPs) linked to each condition. The main analysis employed the random-effects inverse-variance weighted (IVW) method, supplemented by MR-Egger regression and the weighted median approach to strengthen the robustness of the findings.

Results: The IVW analysis identified a significant link between depression and a heightened risk of several ARDs: Sjögren's syndrome (OR = 1.546, p < .001), fibromyalgia syndrome (OR = 5.000, p < .001), psoriasis (OR = 1.185, p = .009), and psoriatic arthritis (OR = 1.333, p = .01). No association was found for rheumatoid arthritis, systemic lupus erythematosus, rheumatic polymyalgia, systemic sclerosis, gout, polymyositis, or Behçet's disease. These results were consistent across the MR-Egger and weighted median analyses. The reverse MR analysis found no significant causal effect of any ARD on depression risk.

Conclusions: In conclusion, this MR study suggests that individuals with depression are at high risk for certain ARDs, highlighting the importance of timely screening, early detection, and intervention. Additional studies are required to elucidate the exact connection and mechanisms linking depression with particular ARDs.

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自身免疫性风湿病与抑郁症之间的关系：双样本双向孟德尔随机化

背景：虽然先前的观察性研究表明抑郁症与自身免疫性风湿性疾病（ARDs）之间存在关联，但潜在的因果关系尚不清楚。方法：采用双样本双向孟德尔随机化（MR）研究，探讨抑郁与ARDs之间的因果关系。抑郁症和ARDs的遗传数据均来自公开的遗传数据集。工具变量被选择为与每个条件相关的独立单核苷酸多态性（snp）。主要分析采用随机效应反方差加权（IVW）方法，辅以MR-Egger回归和加权中位数法，以增强研究结果的稳健性。结果：IVW分析确定了抑郁与几种ARDs风险增加之间的显著联系：Sjögren综合征（OR = 1.546, p = 0.009）和银屑病关节炎（OR = 1.333, p = 0.01）。类风湿关节炎、系统性红斑狼疮、风湿性多肌痛、系统性硬化症、痛风、多肌炎或behet病未发现相关性。这些结果在MR-Egger和加权中位数分析中是一致的。反向磁共振分析发现，任何ARD对抑郁风险都没有显著的因果关系。结论：综上所述，本MR研究提示抑郁症患者发生某些ARDs的风险较高，强调了及时筛查、早期发现和干预的重要性。需要进一步的研究来阐明抑郁症与特定ARDs之间的确切联系和机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatry-Interpersonal and Biological Processes 医学-精神病学

CiteScore

2.70

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Internationally recognized, Psychiatry has responded to rapid research advances in psychiatry, psychology, neuroscience, trauma, and psychopathology. Increasingly, studies in these areas are being placed in the context of human development across the lifespan, and the multiple systems that influence individual functioning. This journal provides broadly applicable and effective strategies for dealing with the major unsolved problems in the field.