Optimizing Helical Tomotherapy for Left-Sided Breast Cancer: A Retrospective Dosimetric Study of a Novel Virtual Organ-Arc Block.

IF 2.8 4区 医学 Q3 ONCOLOGY
Technology in Cancer Research & Treatment Pub Date : 2025-01-01 Epub Date: 2025-07-25 DOI:10.1177/15330338251363288
Yingtao Fang, Wenliang Yu, Jian Qiao, Yanju Yang, Jing Mi, Lei Yu, Ying Guo, Jiazhou Wang, Weigang Hu
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引用次数: 0

Abstract

IntroductionLeft-sided breast cancer radiotherapy requires precise dose modulation to balance target coverage and organ-at-risk (OAR) sparing. This study evaluates a novel Organ and Arc-based Directional Block (OABD Block) in helical tomotherapy planning to address this challenge.MethodsIn this single-institutional retrospective study, 10 post-mastectomy patients with left-sided breast cancer receiving adjuvant radiotherapy were studied. Target volumes included chest wall, internal mammary, axillary, and supraclavicular lymph nodes, with a dose of 50 Gy over 25 fractions. Using a tomotherapy planning system, an OABD Block was configured to incorporate arc structures and protect organs-at-risk. For each patient, helical tomotherapy plans were prepared with and without the OABD Block, keeping field width, pitch, and modulation factors identical. Additionally, static intensity-modulated radiotherapy (IMRT) plans were created on a United Imaging system. Treatment plans were evaluated by dose-volume parameters, conformity and homogeneity indices, and mean doses to targets and normal tissues.ResultsHelical tomotherapy with the OABD Block provided a mean conformity Index of 0.79 for the Planning Target Volume, higher than plans without the block (0.73) but below IMRT plans (0.88). The homogeneity Index averaged 0.14 with the block, 0.18 without, and 0.11 in IMRT. For the internal mammary lymph node region, D95% reached 5007.7 cGy with the block, compared to 5001.1 cGy without and 4897.9 cGy in IMRT. The OABD Block reduced the mean heart dose to 478.7 cGy, compared to 533.5 cGy without and 638.9 cGy in IMRT. Left lung V5 was 48.0% with the block, 52.7% without, and 53.2% in IMRT; V20 was also lowest with the block (17.5%) versus without (20.3%) and IMRT (24.3%).ConclusionAdding the OABD Block to helical tomotherapy improved internal mammary lymph node dose coverage and reduced exposure to organs at risk.

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优化左侧乳腺癌螺旋断层治疗:一种新型虚拟器官-弧形块的回顾性剂量学研究。
左侧乳腺癌放疗需要精确的剂量调节来平衡靶覆盖和器官风险(OAR)保留。本研究评估了一种新的器官和弧形定向阻滞(OABD阻滞)在螺旋断层治疗计划中解决这一挑战。方法对10例左侧乳腺癌乳腺切除术后接受辅助放疗的患者进行单机构回顾性研究。靶体积包括胸壁、乳腺内、腋窝和锁骨上淋巴结,剂量为50 Gy / 25分。使用断层治疗计划系统,OABD Block被配置成包含弧形结构并保护处于危险中的器官。对于每个患者,在有或没有OABD块的情况下,准备螺旋断层治疗计划,保持视野宽度、间距和调制因子相同。此外,在United Imaging系统上创建了静态调强放疗(IMRT)计划。通过剂量-体积参数、一致性和均匀性指数以及靶组织和正常组织的平均剂量对治疗方案进行评价。结果OABD阻滞的ct治疗对计划目标体积的平均符合指数为0.79,高于未阻滞的计划(0.73),但低于IMRT计划(0.88)。均匀性指数平均为0.14块,0.18无,0.11在IMRT。对于乳腺内淋巴结区域,阻断后D95%达到5007.7 cGy,而未阻断时为5001.1 cGy, IMRT时为4897.9 cGy。OABD阻断将平均心脏剂量降低至478.7 cGy,而IMRT组为533.5 cGy, IMRT组为638.9 cGy。左肺V5有阻断的占48.0%,无阻断的占52.7%,IMRT组占53.2%;阻滞组的V20也最低(17.5%),而非阻滞组(20.3%)和IMRT组(24.3%)。结论在螺旋ct治疗中加入OABD阻断剂可改善内乳淋巴结剂量覆盖,减少对危险器官的暴露。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
202
审稿时长
2 months
期刊介绍: Technology in Cancer Research & Treatment (TCRT) is a JCR-ranked, broad-spectrum, open access, peer-reviewed publication whose aim is to provide researchers and clinicians with a platform to share and discuss developments in the prevention, diagnosis, treatment, and monitoring of cancer.
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