Comparison of clinicopathological features of gastric carcinoma in autoimmune gastritis with and without Helicobacter pylori infection.

IF 5.1 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Gastric Cancer Pub Date : 2025-07-25 DOI:10.1007/s10120-025-01649-z

Ayaka Takasu, Toshiaki Hirasawa, Yuka Higashi, Kaoru Nakano, Souya Nunobe, Takuji Gotoda, Hiroshi Kawachi

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引用次数: 0

Abstract

Background: Chronic atrophic gastritis, represented by Helicobacter pylori (H. pylori) or autoimmune gastritis (AIG), has been recognized as a risk factor for gastric carcinoma (GC). Differences in the clinicopathological features of GC with AIG (GC-AIG) based on H. pylori infection status remain unclear.

Methods: This retrospective analysis included 65 cases of GC-AIG in which endoscopic resection or gastrectomy was performed at a single center between 2008 and 2024. The cases were categorized into Group A (H. pylori-naïve GC-AIG) or Group B (H. pylori-infected GC-AIG), and the clinical and pathological data were compared between the groups.

Results: Group A included 18 cases with 25 lesions and Group B included 47 cases with 72 lesions. The median age [interquartile range] was significantly younger in Group A (70 [63-74] years) than in Group B (75 [62-79] years, p = 0.045). Tumors in Group A were more frequently located in the upper and middle stomach, whereas those in Group B were predominantly located in the lower stomach (p = 0.006). Group A had a significantly higher proportion of pure undifferentiated-type adenocarcinoma (Laurén's diffuse type) than Group B (28.0% versus 8.3%, p = 0.027).

Conclusions: H. pylori-naïve GC-AIG is characterized by younger age, a higher prevalence of pure undifferentiated-type adenocarcinoma, and tumors predominantly located in the upper and middle stomach.

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自身免疫性胃炎伴幽门螺杆菌感染与不伴幽门螺杆菌感染的胃癌临床病理特征比较。

背景：以幽门螺杆菌（h.p ylori）或自身免疫性胃炎（AIG）为代表的慢性萎缩性胃炎已被认为是胃癌（GC）的危险因素。基于幽门螺杆菌感染状态的GC-AIG临床病理特征的差异尚不清楚。方法：回顾性分析2008年至2024年间在单中心行内镜切除或胃切除术的65例GC-AIG病例。将病例分为A组（h.p ypylori-naïve GC-AIG）和B组（h.p ylori-感染GC-AIG），比较两组的临床和病理资料。结果：A组18例，病变25例；B组47例，病变72例。A组患者的中位年龄（70[63-74]岁）明显低于B组（75[62-79]岁，p = 0.045）。A组肿瘤多位于胃中上部，B组肿瘤多位于胃下部（p = 0.006）。A组纯未分化型腺癌（lauracemon弥漫性腺癌）的比例明显高于B组（28.0%比8.3%,p = 0.027）。结论：h.p pylori-naïve GC-AIG的特点是年龄较小，纯未分化型腺癌患病率较高，肿瘤主要位于胃上部和中部。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gastric Cancer 医学-胃肠肝病学

CiteScore

14.70

自引率

2.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Gastric Cancer is an esteemed global forum that focuses on various aspects of gastric cancer research, treatment, and biology worldwide. The journal promotes a diverse range of content, including original articles, case reports, short communications, and technical notes. It also welcomes Letters to the Editor discussing published articles or sharing viewpoints on gastric cancer topics. Review articles are predominantly sought after by the Editor, ensuring comprehensive coverage of the field. With a dedicated and knowledgeable editorial team, the journal is committed to providing exceptional support and ensuring high levels of author satisfaction. In fact, over 90% of published authors have expressed their intent to publish again in our esteemed journal.