Biotransformation research advances - 2024 year in review.

Abstract

This is the ninth installment of this annual review. In line with previous years, the primary objective is to highlight articles deemed by us of significant interest in the broad field of biotransformation. Sixteen manuscripts have been collated and presented herein accompanied by a synopsis, commentary and relevant figures. This year's collection delves into five main areas: 1) the metabolism and disposition of various investigative and approved drugs, 2) non-CYP enzymatic biotransformation, 3) novel models and approaches; 4) the role of gut microbiota, and 5) modulating drug-metabolizing enzyme activities.