Associations of serum carotene levels and decline for the ability of attention: a longitudinal study in the Japanese general population.

IF 2.5 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Hiroshi Okumiyama, Yoshiki Tsuboi, Ryosuke Fujii, Akihiko Iwahara, Takeshi Hatta, Shuntaro Sato, Hiroya Yamada, Koji Suzuki
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引用次数: 0

Abstract

Background: Although serum carotene may contribute to dementia prevention, there is a lack of longitudinal evidence for early cognitive decline before dementia symptoms. The aim of this study was to examine whether serum carotene levels were associated with annually evaluated cognitive trajectories among the Japanese general population.

Methods: Among 581 baseline participants, 199 individuals (83 males; mean age [min, max], 62.7 [39, 90] years) who underwent cognitive assessments more than twice after baseline were analyzed. "Attention" levels were assessed using one- and three-target Digit Cancellation Tests (D-CAT1 and D-CAT3). "General cognitive ability" was assessed by the short version of Mini-Mental State Examination (SMMSE). Serum carotenes (α-carotene, β-carotene and lycopene) were measured by high-performance liquid chromatography. After the measurements, we calculated total carotene levels by summing up the levels of all measured carotene. Carotene levels were categorized into three groups for analysis (low: 0%-25%, middle: 25%-75%, and high: 75%-100%). A linear mixed model was used to estimate the slope of the D-CAT score trajectory and to compare it between three categories.

Results: Compared with the middle carotene group, decline of attention was faster in the D-CAT1 for low β-carotene (β = -3.48, p = 0.035), lycopene (β = -3.10, p = 0.062), and total carotene (β = -4.75, p = 0.003), but not for α-carotene (β = -2.60, p = 0.111). For the D-CAT3, decline of attention was faster in the group of low lycopene (β = -3.17, p = 0.002) and total carotene (β = -2.17, p = 0.037) compared with the middle carotene group, while no clear association for α-carotene (β = -0.67, p = 0.521) and β-carotene (β = -0.64, p = 0.639). There were no clear associations between serum carotene and the SMMSE score.

Conclusions: These findings suggest low levels of serum lycopene are associated with a decline of attention in the setting of the general population.

血清胡萝卜素水平与注意力能力下降的关系:一项日本普通人群的纵向研究。
背景:虽然血清胡萝卜素可能有助于预防痴呆,但缺乏痴呆症状前早期认知能力下降的纵向证据。本研究的目的是研究血清胡萝卜素水平是否与日本普通人群每年评估的认知轨迹有关。方法:在581名基线参与者中,199人(83名男性;平均年龄[min, max], 62.7[39,90]岁)在基线后接受两次以上认知评估者进行分析。使用单目标和三目标数字消除测试(D-CAT1和D-CAT3)评估“注意力”水平。一般认知能力采用简易精神状态测验(SMMSE)评估。采用高效液相色谱法测定血清中α-胡萝卜素、β-胡萝卜素和番茄红素的含量。测量后,我们通过将所有测量到的胡萝卜素的水平相加来计算总胡萝卜素水平。胡萝卜素水平分为三组进行分析(低:0%-25%,中:25%-75%,高:75%-100%)。使用线性混合模型估计D-CAT评分轨迹的斜率,并在三类之间进行比较。结果:与中胡萝卜素组相比,低β-胡萝卜素组(β = -3.48, p = 0.035)、番茄红素组(β = -3.10, p = 0.062)、总胡萝卜素组(β = -4.75, p = 0.003)的D-CAT1注意力下降较快,α-胡萝卜素组(β = -2.60, p = 0.111)的D-CAT1注意力下降较慢。对于D-CAT3,低番茄红素组(β = -3.17, p = 0.002)和总胡萝卜素组(β = -2.17, p = 0.037)的注意力下降速度快于中等胡萝卜素组,α-胡萝卜素组(β = -0.67, p = 0.521)和β-胡萝卜素组(β = -0.64, p = 0.639)的注意力下降速度快于中等胡萝卜素组。血清胡萝卜素与SMMSE评分之间没有明确的关联。结论:这些发现表明,在普通人群中,血清番茄红素水平低与注意力下降有关。
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来源期刊
Environmental Health and Preventive Medicine
Environmental Health and Preventive Medicine PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -
CiteScore
7.90
自引率
2.10%
发文量
44
审稿时长
10 weeks
期刊介绍: The official journal of the Japanese Society for Hygiene, Environmental Health and Preventive Medicine (EHPM) brings a comprehensive approach to prevention and environmental health related to medical, biological, molecular biological, genetic, physical, psychosocial, chemical, and other environmental factors. Environmental Health and Preventive Medicine features definitive studies on human health sciences and provides comprehensive and unique information to a worldwide readership.
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