Sustainable Imine Production Using Alkanes as Substrates via a Plasma-Microdroplet Approach.

IF 14.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Shuang Sun,Yijie Fu,Xiangrui Bu,Qinhao Shi,Weilong Wu,Xinghui Li,Xiaohao Wang,Quan Yu
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引用次数: 0

Abstract

The direct functionalization of alkanes remains a formidable challenge in synthetic chemistry. Herein, we present an integrated plasma-microdroplet approach for the efficient conversion of alkanes into imines under mild conditions. By employing plasma discharge in a nitrogen atmosphere, inert C-H bonds are selectively activated, generating abundant N-insertion intermediates. These species are then captured by electrosprayed microdroplets, where they undergo rapid transimination with gaseous primary amines, yielding imines with high efficiency. Real-time mass spectrometry analysis reveals a two-step mechanism: initial plasma-driven alkane functionalization followed by microdroplet-accelerated transimination. By synergistically combining the high activation capability of nonthermal plasma with the enhanced reaction dynamics of microdroplets, this method establishes a green alternative to conventional thermal catalysis for sustainable chemical transformation from inert substrates.
以烷烃为底物的等离子体微滴法可持续生产亚胺。
烷烃的直接官能化仍然是合成化学中的一个巨大挑战。在此,我们提出了一种集成的等离子体微滴方法,用于在温和条件下将烷烃有效转化为亚胺。通过在氮气气氛中使用等离子体放电,惰性碳氢键被选择性激活,产生丰富的n插入中间体。这些物种然后被电喷雾微滴捕获,在那里它们与气态伯胺快速转化,高效率地产生亚胺。实时质谱分析揭示了一个两步机制:初始等离子体驱动的烷烃功能化,然后是微滴加速的透射。通过将非热等离子体的高活化能力与微滴增强的反应动力学协同结合,该方法建立了一种替代传统热催化的绿色方法,用于惰性基质的可持续化学转化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
24.40
自引率
6.00%
发文量
2398
审稿时长
1.6 months
期刊介绍: The flagship journal of the American Chemical Society, known as the Journal of the American Chemical Society (JACS), has been a prestigious publication since its establishment in 1879. It holds a preeminent position in the field of chemistry and related interdisciplinary sciences. JACS is committed to disseminating cutting-edge research papers, covering a wide range of topics, and encompasses approximately 19,000 pages of Articles, Communications, and Perspectives annually. With a weekly publication frequency, JACS plays a vital role in advancing the field of chemistry by providing essential research.
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