Analysis of risk factors for perioperative hyperamylasemia in kidney transplant recipients.

IF 3 3区医学 Q1 UROLOGY & NEPHROLOGY

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-07-23 DOI:10.1080/0886022X.2025.2529444

Yang Zhang, Liubing Xia, You Luo, Jinhua Zhang, Zoufu Tang, Xiaorong Chen, Ning Na

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引用次数: 0

Abstract

Background: Perioperative hyperamylasemia has been observed in several kidney transplant recipients (KTRs) at our center. However, there are currently no published reports on this observation. This study aimed to identify the risk factors associated with perioperative hyperamylasemia in KTRs.

Methods: The data from 540 deceased-donor kidney recipients in our hospital from January 2020 to December 2023 were retrospectively analyzed. Variables such as gender, past medical history, relevant laboratory tests, and trough concentration of calcineurin inhibitors (CNIs) at the time of serum amylase maximum were collected for all patients. Univariate and multivariate logistic regression analyses were used to determine the risk factors associated with perioperative hyperamylasemia.

Results: Among all KTRs, 153 patients (28.3%) developed perioperative hyperamylasemia. Multivariate logistic regression analysis indicated that preoperative serum phosphate (odds ratio [OR] = 1.62, 95% confidence interval [CI]: 1.160 - 2.266, p = 0.005), preoperative serum amylase (OR = 1.01, 95% CI: 1.006 - 1.015, p < 0.001), and high perioperative CNIs trough concentration (OR = 2.335, 95% CI: 1.560 - 3.494, p < 0.001) were risk factors associated with perioperative hyperamylasemia. In addition, we used all three as a hybrid model to predict perioperative hyperamylasemia, which demonstrated good predictive value (area under the ROC curve [AUC] = 0.687, 95% CI: 0.64-0.734).

Conclusion: Elevated preoperative serum phosphate levels, preoperative serum amylase levels, and high perioperative CNIs trough concentrations are risk factors for perioperative hyperamylasemia. This study may provide valuable insights for clinicians to identify the causes of perioperative hyperamylasemia and formulate prevention and treatment strategies.

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肾移植受者围手术期高淀粉酶血症的危险因素分析。

背景：在我们中心的几个肾移植受者（KTRs）中观察到围手术期高淀粉酶血症。然而，目前还没有关于这一观察结果的发表报告。本研究旨在确定与ktr围手术期高淀粉酶血症相关的危险因素。方法：回顾性分析2020年1月至2023年12月我院540例死亡供肾受者的资料。收集所有患者的性别、既往病史、相关实验室检查和血清淀粉酶最大值时钙调磷酸酶抑制剂（CNIs）谷浓度等变量。采用单因素和多因素logistic回归分析确定围手术期高淀酵酶血症的相关危险因素。结果：153例（28.3%）患者出现围手术期高淀粉酶血症。多因素logistic回归分析显示，术前血清磷酸盐（比值比[OR] = 1.62, 95%可信区间[CI]: 1.160 ~ 2.266, p = 0.005）、术前血清淀粉酶（OR = 1.01, 95% CI: 1.006 ~ 1.015, p p）、围手术期血清磷酸盐水平升高、血清淀粉酶水平升高、围手术期CNIs谷浓度高是围手术期高淀粉酶血症的危险因素。本研究可为临床医生鉴别围手术期高淀粉酶血症的病因，制定预防和治疗策略提供有价值的见解。

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来源期刊

Renal Failure 医学-泌尿学与肾脏学

CiteScore

3.90

自引率

13.30%

发文量

374

审稿时长

1 months

期刊介绍： Renal Failure primarily concentrates on acute renal injury and its consequence, but also addresses advances in the fields of chronic renal failure, hypertension, and renal transplantation. Bringing together both clinical and experimental aspects of renal failure, this publication presents timely, practical information on pathology and pathophysiology of acute renal failure; nephrotoxicity of drugs and other substances; prevention, treatment, and therapy of renal failure; renal failure in association with transplantation, hypertension, and diabetes mellitus.