Experimental test of the fitness effects of divergent marine-freshwater chromosomal inversions in stickleback under different salinity conditions.

IF 3.9 2区 生物学 Q2 ECOLOGY
Juliana Rodríguez-Fuentes, Nicole Nesvadba, Verena Saladin, Marius Roesti, Catherine L Peichel
{"title":"Experimental test of the fitness effects of divergent marine-freshwater chromosomal inversions in stickleback under different salinity conditions.","authors":"Juliana Rodríguez-Fuentes, Nicole Nesvadba, Verena Saladin, Marius Roesti, Catherine L Peichel","doi":"10.1038/s41437-025-00784-8","DOIUrl":null,"url":null,"abstract":"<p><p>Chromosomal inversions are a type of structural variant that have long interested evolutionary biologists because of their potential role in local adaptation and speciation. However, direct experimental evidence for the fitness consequences of inversions is rare, limiting our ability to dissect the evolutionary forces associated with the spread and maintenance of inversions in natural populations. We tackle this knowledge gap by studying the fitness effects of three chromosomal inversions that consistently differ between marine and freshwater populations of threespine sticklebacks (Gasterosteus aculeatus). Using controlled laboratory crosses, we tested whether inversion genotype influences fitness (measured as survival, standard length, and body condition) across two salinity treatments (freshwater vs saltwater). In both the freshwater and the saltwater treatments, there were no deviations from Mendelian ratios at any of the three inversions. This suggests that there are no intrinsic deleterious effects of these inversions, in contrast to observations from other systems. Overall, there was no effect of inversion genotype on standard length or body size across the two salinity treatments for the chromosome XI and XXI inversions. For the chromosome I inversion, heterozygotes had a slightly lower body condition in the freshwater treatment. Together, these results suggest that the fitness effects of these inversions are not strongly influenced by salinity and that other selective forces might be involved in their evolution. More broadly, these findings highlight the importance of performing empirical tests of fitness effects of chromosomal inversions to better explain their spread and maintenance in nature.</p>","PeriodicalId":12991,"journal":{"name":"Heredity","volume":" ","pages":""},"PeriodicalIF":3.9000,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Heredity","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1038/s41437-025-00784-8","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ECOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Chromosomal inversions are a type of structural variant that have long interested evolutionary biologists because of their potential role in local adaptation and speciation. However, direct experimental evidence for the fitness consequences of inversions is rare, limiting our ability to dissect the evolutionary forces associated with the spread and maintenance of inversions in natural populations. We tackle this knowledge gap by studying the fitness effects of three chromosomal inversions that consistently differ between marine and freshwater populations of threespine sticklebacks (Gasterosteus aculeatus). Using controlled laboratory crosses, we tested whether inversion genotype influences fitness (measured as survival, standard length, and body condition) across two salinity treatments (freshwater vs saltwater). In both the freshwater and the saltwater treatments, there were no deviations from Mendelian ratios at any of the three inversions. This suggests that there are no intrinsic deleterious effects of these inversions, in contrast to observations from other systems. Overall, there was no effect of inversion genotype on standard length or body size across the two salinity treatments for the chromosome XI and XXI inversions. For the chromosome I inversion, heterozygotes had a slightly lower body condition in the freshwater treatment. Together, these results suggest that the fitness effects of these inversions are not strongly influenced by salinity and that other selective forces might be involved in their evolution. More broadly, these findings highlight the importance of performing empirical tests of fitness effects of chromosomal inversions to better explain their spread and maintenance in nature.

不同盐度条件下棘鱼不同海水-淡水染色体倒位适合度效应的实验研究。
染色体倒位是进化生物学家长期感兴趣的一种结构变异,因为它们在局部适应和物种形成中具有潜在的作用。然而,直接的实验证据证明逆行的适应性后果是罕见的,这限制了我们剖析与自然种群中逆行的传播和维持相关的进化力量的能力。我们通过研究三刺棘鱼(Gasterosteus aculeatus)在海洋和淡水种群之间始终存在差异的三个染色体倒位的适合度效应来解决这一知识差距。通过控制实验室杂交,我们测试了反转基因型是否会影响两种盐度处理(淡水和盐水)的适合度(以存活率、标准长度和身体状况来衡量)。在淡水和盐水处理中,在三种反转中,孟德尔比率都没有偏差。这表明,与其他系统的观测结果相比,这些逆温没有内在的有害影响。总体而言,在两种盐度处理中,对染色体XI和XXI的倒位基因型对标准长度或体大小没有影响。对于I号染色体反转,淡水处理的杂合子体状态略低。总之,这些结果表明,这些反转的适合度效应不受盐度的强烈影响,其他选择力可能参与了它们的进化。更广泛地说,这些发现强调了对染色体倒位的适应性效应进行实证测试的重要性,以更好地解释它们在自然界的传播和维持。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Heredity
Heredity 生物-进化生物学
CiteScore
7.50
自引率
2.60%
发文量
84
审稿时长
4-8 weeks
期刊介绍: Heredity is the official journal of the Genetics Society. It covers a broad range of topics within the field of genetics and therefore papers must address conceptual or applied issues of interest to the journal''s wide readership
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信