Radiological Stage of Hemophilic Arthropathy of Knee Does Not Correlate With Clinical Variables

IF 3 2区医学 Q2 HEMATOLOGY

Haemophilia Pub Date : 2025-07-23 DOI:10.1111/hae.70088

Arman Vahabi, Erdem Er, Abdussamet Kuyucu, Elcil Kaya Biçer, Semih Aydoğdu

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Abstract

Background

Various functional and radiological systems have been developed to evaluate joint health and the severity of arthropathy in hemophilic patients. Clinical relevance of these radiological systems has received minimal attention.

Methods

Through a retrospective chart review, 84 patients with end-stage hemophilic arthropathy of the knee were included. Pettersson and Arnold–Hilgartner scores were assessed by two observers. Correlation between radiological stage and range of motion (ROM), KSS function subscores, KSS pain subscores, total KSS, and surgical time were analyzed.

Results

Interobserver correlation was found to be very strong for Pettersson score, with a value of 0.84 (95% CI: 0.75–0.89) and moderate for the Arnold–Hilgartner with kappa value of 0.4 (95% CI: 0.17–0.62). Correlation between Pettersson score and clinical variables revealed a very weak inverse correlation with ROM (r = −0.12, 95% CI: −0.33 to 0.10), KSS pain (r = −0.09, 95% CI: −0.31 to 0.12), and KSS function (r = −0.16, 95% CI: −0.36 to 0.06), and weak inverse correlation with KSS (r = −0.24, 95% CI: −0.44 to 0.2). Regarding the correlation between Arnold–Hilgartner score, a weak inverse correlation was observed with ROM (r = −0.21, 95% CI: −0.41 to 0.00), and very weak inverse correlations with KSS pain (r = −0.06, 95% CI: −0.16 to 0.27), KSS function (r = −0.00, 95% CI: −0.22 to 0.21), and KSS (r = −0.04, 95% CI: −0.25 to 0.18).

Conclusion

Radiologic staging systems demonstrate weak correlation with clinically meaningful variables in patients with end-stage hemophilic arthropathy of knee, an important consideration in the management of hemophilic arthropathy.

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膝关节血友病的放射分期与临床变量无关。

背景：已经开发了各种功能和放射学系统来评估血友病患者的关节健康和关节病的严重程度。这些放射学系统的临床相关性很少受到关注。方法：回顾性分析84例终末期膝关节血友病患者的临床资料。Pettersson和Arnold-Hilgartner分数由两名观察员评估。分析放射分期与活动度（ROM）、KSS功能评分、KSS疼痛评分、KSS总评分和手术时间的相关性。结果：petersson评分的观察者间相关性非常强，kappa值为0.84 (95% CI: 0.75-0.89)， Arnold-Hilgartner的观察者间相关性中等，kappa值为0.4 （95% CI: 0.17-0.62）。Pettersson评分与临床变量的相关性显示，与ROM （r = -0.12, 95% CI: -0.33 ~ 0.10）、KSS疼痛（r = -0.09, 95% CI: -0.31 ~ 0.12）和KSS功能（r = -0.16, 95% CI: -0.36 ~ 0.06）呈极弱负相关（r = -0.24, 95% CI: -0.44 ~ 0.2）。Arnold-Hilgartner评分与ROM （r = -0.21, 95% CI: -0.41 ~ 0.00）呈弱负相关，与KSS疼痛（r = -0.06, 95% CI: -0.16 ~ 0.27）、KSS功能（r = -0.00, 95% CI: -0.22 ~ 0.21）和KSS （r = -0.04, 95% CI: -0.25 ~ 0.18）呈极弱负相关。结论：在终末期膝关节血友病患者中，放射分期系统与临床有意义的变量相关性较弱，这是血友病关节病治疗的重要考虑因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Haemophilia 医学-血液学

CiteScore

6.50

自引率

28.20%

发文量

226

审稿时长

3-6 weeks

期刊介绍： Haemophilia is an international journal dedicated to the exchange of information regarding the comprehensive care of haemophilia. The Journal contains review articles, original scientific papers and case reports related to haemophilia care, with frequent supplements. Subjects covered include: clotting factor deficiencies, both inherited and acquired: haemophilia A, B, von Willebrand''s disease, deficiencies of factor V, VII, X and XI replacement therapy for clotting factor deficiencies component therapy in the developing world transfusion transmitted disease haemophilia care and paediatrics, orthopaedics, gynaecology and obstetrics nursing laboratory diagnosis carrier detection psycho-social concerns economic issues audit inherited platelet disorders.