Yuehua Li, Lei Zheng, Wenjie Cheng, Bozhi Hou, Raymond Chung Wen Wong
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引用次数: 0
Abstract
Heparan sulfate (HS) is synthesized in majority of cells in the human body and is typically released as an extension of polysaccharide chains, which then covalently bind to the protein core of proteoglycans to form heparan sulfate proteoglycans (HSPG). Research has shown that HS plays a crucial role in various cellular pathways of bone repair and regeneration and this review aims to summarize the role of HS in the above process. We found that the specific role of HS in bone repair and regeneration may depend on its location by analyzing the published research. Compared to cell surface HS, research on extracellular matrix (ECM) HS is limited. The current research suggests that HS can prevent the formation of blood clots after bone fracture and has a dual role in inflammation. ECM HS promotes soft callus formation and mineralization, while cell surface HS has inhibitory effects.
期刊介绍：
Calcified Tissue International and Musculoskeletal Research publishes original research and reviews concerning the structure and function of bone, and other musculoskeletal tissues in living organisms and clinical studies of musculoskeletal disease. It includes studies of cell biology, molecular biology, intracellular signalling, and physiology, as well as research into the hormones, cytokines and other mediators that influence the musculoskeletal system. The journal also publishes clinical studies of relevance to bone disease, mineral metabolism, muscle function, and musculoskeletal interactions.
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