Investigation of Individual Variability and Temporal Fluctuations in Exhaled Nitric Oxide (FeNO) Levels in Healthy Individuals.

IF 2.3 Q3 RESPIRATORY SYSTEM

Advances in respiratory medicine Pub Date : 2025-07-21 DOI:10.3390/arm93040026

Emi Yuda, Tomoki Ando, Yukihiro Ishida, Hiroyuki Sakano, Yutaka Yoshida

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Abstract

Measurement of nitric oxide (NO) concentration in exhaled breath (FeNO) is a quantitative, non-invasive, simple, and safe method for assessing airway inflammation. It serves as a complementary tool to other methods for evaluating airway diseases. However, little is known about the typical NO levels in healthy individuals, including individual differences and the influence of measurement timing. Therefore, this study classified measurement times into four periods and statistically analyzed NO levels in healthy individuals. The mean values among groups were compared using repeated measures ANOVA on six participants. The analysis showed large individual variations in NO levels, resulting in no significant difference (p = 0.29). Notably, greater fluctuations were observed in the morning. These findings align with previous studies suggesting the influence of circadian rhythms and the redundancy of repeated measurements. This study highlights the need to consider timing and individual variability when using FeNO as a physiological marker in healthy populations.

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健康个体呼出一氧化氮（FeNO）水平的个体变异和时间波动的研究。

呼气中一氧化氮（NO）浓度的测定是一种定量、无创、简单、安全的评估气道炎症的方法。它是评估气道疾病的其他方法的补充工具。然而，对于健康个体的典型NO水平，包括个体差异和测量时间的影响，了解甚少。因此，本研究将测量次数分为4个时间段，对健康个体的NO水平进行统计分析。对6名受试者采用重复测量方差分析比较各组平均值。分析显示NO水平存在较大的个体差异，差异无统计学意义（p = 0.29）。值得注意的是，上午的波动更大。这些发现与先前的研究一致，表明昼夜节律的影响和重复测量的冗余。本研究强调，在健康人群中使用FeNO作为生理标志物时，需要考虑时间和个体差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in respiratory medicine RESPIRATORY SYSTEM-

CiteScore

2.60

自引率

0.00%

发文量

期刊介绍： "Advances in Respiratory Medicine" is a new international title for "Pneumonologia i Alergologia Polska", edited bimonthly and addressed to respiratory professionals. The Journal contains peer-reviewed original research papers, short communications, case-reports, recommendations of the Polish Respiratory Society concerning the diagnosis and treatment of lung diseases, editorials, postgraduate education articles, letters and book reviews in the field of pneumonology, allergology, oncology, immunology and infectious diseases. "Advances in Respiratory Medicine" is an open access, official journal of Polish Society of Lung Diseases, Polish Society of Allergology and National Research Institute of Tuberculosis and Lung Diseases.