A Comparison of Impulse Oscillometry and Spirometry by Percent Predicted in Identifying Uncontrolled Asthma.

IF 2.3 Q3 RESPIRATORY SYSTEM

Advances in respiratory medicine Pub Date : 2025-07-18 DOI:10.3390/arm93040025

Chalerm Liwsrisakun, Chaicharn Pothirat, Athavudh Deesomchok, Pilaiporn Duangjit, Warawut Chaiwong

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Abstract

Background: The role of impulse oscillometry (IOS) in evaluating asthma control remains a challenge because the interpretation varies by many factors, including ethnicity. We aimed to assess the diagnostic contribution of spirometry and IOS, established from reference equations, in the detection of uncontrolled asthma.

Methods: This retrospective study was conducted in adult asthma subjects with normal spirometry. Uncontrolled asthma was defined as an Asthma Control Test (ACT) score ≤ 19. Receiver operating characteristic (ROC) curves were plotted to compare the diagnostic abilities of the %-predicted of heterogeneity of resistance at 5 Hz and 20 Hz (R5-R20) and the %-predicted of forced expiratory volume in the first second (FEV₁) in detecting uncontrolled asthma. Multivariable risk regressions were performed to identify the %-predicted of R5-R20 as a predictor for uncontrolled asthma.

Results: The %-predicted of R5-R20 demonstrated a superior diagnostic ability for detecting uncontrolled asthma compared to the %-predicted FEV₁, with the area under the ROC curves (AuROC) = 0.939 vs. 0.712, respectively, p < 0.001. The %-predicted R5R20 of ≥200 showed the highest AuROC for detecting uncontrolled asthma with an adjusted risk ratio of 10.86 (95%CI; 3.77, 31.29; p < 0.001).

Conclusions: IOS demonstrated better diagnostic ability for detecting uncontrolled asthma than spirometry.

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脉冲振荡法与肺活量测定法在诊断未控制哮喘中的预测百分率比较。

背景：脉冲振荡测量（IOS）在评估哮喘控制中的作用仍然是一个挑战，因为其解释因许多因素而异，包括种族。我们的目的是评估肺活量测定法和由参考方程建立的IOS在检测未控制哮喘中的诊断贡献。方法：对肺活量正常的成人哮喘患者进行回顾性研究。未控制哮喘定义为哮喘控制测试（ACT）评分≤19分。绘制受试者工作特征（ROC）曲线，比较5hz和20hz阻力异质性的预测% （R5-R20）和第一秒用力呼气量（FEV1）的预测%对未控制哮喘的诊断能力。进行多变量风险回归，以确定R5-R20的预测百分比作为未控制哮喘的预测因子。结果：R5-R20的%-预测值比FEV1的%-预测值对未控制哮喘的诊断能力更强，ROC曲线下面积（AuROC）分别为0.939比0.712,p < 0.001。R5R20≥200的%预测值显示，检测未控制哮喘的AuROC最高，校正风险比为10.86 (95%CI；3.77、31.29;P < 0.001)。结论：IOS对未控制哮喘的诊断能力优于肺量测定法。

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来源期刊

Advances in respiratory medicine RESPIRATORY SYSTEM-

CiteScore

2.60

自引率

0.00%

发文量

期刊介绍： "Advances in Respiratory Medicine" is a new international title for "Pneumonologia i Alergologia Polska", edited bimonthly and addressed to respiratory professionals. The Journal contains peer-reviewed original research papers, short communications, case-reports, recommendations of the Polish Respiratory Society concerning the diagnosis and treatment of lung diseases, editorials, postgraduate education articles, letters and book reviews in the field of pneumonology, allergology, oncology, immunology and infectious diseases. "Advances in Respiratory Medicine" is an open access, official journal of Polish Society of Lung Diseases, Polish Society of Allergology and National Research Institute of Tuberculosis and Lung Diseases.