Avocado Oil Prevents Neurological and Behavioral Alterations in a Quinolinic Acid-Induced Model of Huntington’s Disease

IF 3.8 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Edith González-Guevara, Pablo Eliasib Martínez-Gopar, Alicia Sánchez-Mendoza, Quetzalli Denisse Angeles-López, Diego López-Orozco, Luis Tristán-López, Mohammed El-Hafidi, Mitzi Daniela Becerril-Cavazos, Claudia Peña-Segura, Carlos Alfredo Silva-Islas, Francisca Pérez-Severiano
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Abstract

Avocado oil is a nutraceutical that offers multiple health benefits due to its rich composition of fatty acids. Avocado’s antioxidant molecules can protect from neuronal damage, potentially preventing or slowing down the onset of neurodegenerative diseases. Within the search for therapeutic targets in neurodegenerative conditions, we focused on testing the neuroprotective effect of the components contained in avocado oil in a Huntington’s disease (HD) model. Quinolinic acid (QA) is a potent striatal excitotoxin that leads to axon-sparing neurodegeneration and induces N-methyl-D-aspartate receptor-mediated cytotoxicity and neuroinflammation. The QA-lesioned rat striatum shares similarities with the neostriatum observed in individuals with HD. This work aimed to study the neuroprotective effects of an avocado oil-supplemented diet on the QA model by measuring neurological and oxidative damage. For this purpose, Wistar rats were fed with an avocado oil-supplemented diet for 20 days. First, evaluated blood biochemical parameters (glucose, cholesterol, and triglycerides) in the blood and testing liver function by the determination of hepatic enzymes levels in plasma and verifying that the avocado oil-supplemented diet did not affect either. Additionally, a second set of rats were fed with an avocado oil-supplemented diet and then lesioned with QA. Our results show that avocado oil supplementation reduces oxidative damage, prevents neurological damage by reducing the ipsilateral turns by maintaining the levels of striatal GABA content, and reduces striatal neurodegeneration assessed by Fluoro-Jade® B. These results suggest that an avocado oil-supplemented diet has a potential role in reducing the negative effects observed in the HD model of the QA intrastriatal administration.

Abstract Image

在喹啉酸诱导的亨廷顿病模型中,鳄梨油可以预防神经和行为的改变。
鳄梨油是一种营养保健品,由于其丰富的脂肪酸成分,可以提供多种健康益处。鳄梨的抗氧化分子可以防止神经元损伤,潜在地预防或减缓神经退行性疾病的发作。在寻找神经退行性疾病的治疗靶点的过程中,我们专注于在亨廷顿病(HD)模型中测试鳄梨油中所含成分的神经保护作用。喹啉酸(QA)是一种有效的纹状体兴奋毒素,可导致保留轴突的神经变性,并诱导n-甲基- d -天冬氨酸受体介导的细胞毒性和神经炎症。qa损伤的大鼠纹状体与HD患者观察到的新纹状体有相似之处。本工作旨在通过测量神经和氧化损伤来研究鳄梨油补充饮食对QA模型的神经保护作用。为此,Wistar大鼠饲喂牛油果油补充饲料20天。首先,评估血液中的生化参数(葡萄糖、胆固醇和甘油三酯),并通过测定血浆中的肝酶水平来检测肝功能,并验证鳄梨油补充饮食对两者都没有影响。此外,第二组大鼠喂食鳄梨油补充饮食,然后用QA损伤。我们的研究结果表明,补充鳄梨油可以减少氧化损伤,通过维持纹状体GABA含量水平来减少同侧旋转,从而防止神经损伤,并减少纹状体神经变性。这些结果表明,鳄梨油补充饮食在减少QA纹状体内给药HD模型中观察到的负面影响方面具有潜在的作用。
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来源期刊
Neurochemical Research
Neurochemical Research 医学-神经科学
CiteScore
7.70
自引率
2.30%
发文量
320
审稿时长
6 months
期刊介绍: Neurochemical Research is devoted to the rapid publication of studies that use neurochemical methodology in research on nervous system structure and function. The journal publishes original reports of experimental and clinical research results, perceptive reviews of significant problem areas in the neurosciences, brief comments of a methodological or interpretive nature, and research summaries conducted by leading scientists whose works are not readily available in English.
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