When human cancer goes neural

IF 44.5 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2025-07-24 DOI:10.1016/j.ccell.2025.07.004

Christina Nürnberg, Sophie Heuer, Frank Winkler

引用次数: 0

Abstract

Invasion along nerves is prognostically detrimental in pancreatic and other cancers, yet its microenvironmental composition in humans remains poorly understood. In this issue of Cancer Cell, Chen et al. present a patient-derived high-resolution spatial and molecular atlas to reveal significant effects of cancer cell invasion on neuro-immuno-oncological and other nerve features.

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当人类的癌症变得神经化

沿神经侵入对胰腺癌和其他癌症的预后是有害的，但其在人类中的微环境组成仍然知之甚少。在这一期的《癌细胞》杂志上，Chen等人展示了一份来自患者的高分辨率空间和分子图谱，揭示了癌细胞侵袭对神经-免疫-肿瘤和其他神经特征的显著影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.