Long interspersed nuclear element 1 methylation in non-small cell lung cancer: implications for diagnosis, prognosis, and therapeutic targeting.

IF 8.2 2区生物学 Q1 CELL BIOLOGY

Cell Communication and Signaling Pub Date : 2025-07-22 DOI:10.1186/s12964-025-02343-4

Dileesha Prabani Wanasundara Arachchillage, Wanvisa Udomsinprasert

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Abstract

Long interspersed nucleotide element 1 (LINE1), the most abundant repetitive element in the human genome, plays a crucial role in genomic instability. Aberrant LINE1 activation, primarily regulated by DNA methylation, is a hallmark of cancer. Non-small cell lung cancer (NSCLC), the most prevalent form of lung cancer worldwide, continues to pose significant challenges due to the invasiveness, high cost, and susceptibility to false positives of current diagnostic methods, as well as the emergence of treatment resistance. This review highlights the potential of LINE1 methylation as a biomarker for NSCLC, offering novel insights into its role in diagnosis, prognosis, and therapeutic strategies. Recent studies uncovered that LINE1 hypomethylation was strongly associated with poor overall survival, suggesting its utility as both a prognostic marker and a therapeutic target. However, further research is required to elucidate its precise regulatory mechanisms in LINE1 retrotransposition and to evaluate its potential as a non-invasive biomarker for improving NSCLC management.

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非小细胞肺癌的长分散核元素1甲基化：对诊断、预后和治疗靶向的影响

长穿插核苷酸元件1 （LINE1）是人类基因组中最丰富的重复元件，在基因组不稳定性中起着至关重要的作用。主要受DNA甲基化调控的异常LINE1激活是癌症的一个标志。非小细胞肺癌（NSCLC）是世界上最常见的肺癌形式，由于现有诊断方法的侵袭性、高成本和对假阳性的易感性，以及治疗耐药性的出现，继续构成重大挑战。这篇综述强调了LINE1甲基化作为非小细胞肺癌生物标志物的潜力，为其在诊断、预后和治疗策略中的作用提供了新的见解。最近的研究发现，LINE1低甲基化与较差的总生存率密切相关，表明其作为预后标志物和治疗靶点的效用。然而，需要进一步的研究来阐明其在LINE1逆转录转位中的精确调控机制，并评估其作为改善非小细胞肺癌管理的非侵入性生物标志物的潜力。

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来源期刊

Cell Communication and Signaling CELL BIOLOGY-

CiteScore

11.00

自引率

0.00%

发文量

180

期刊介绍： Cell Communication and Signaling (CCS) is a peer-reviewed, open-access scientific journal that focuses on cellular signaling pathways in both normal and pathological conditions. It publishes original research, reviews, and commentaries, welcoming studies that utilize molecular, morphological, biochemical, structural, and cell biology approaches. CCS also encourages interdisciplinary work and innovative models, including in silico, in vitro, and in vivo approaches, to facilitate investigations of cell signaling pathways, networks, and behavior. Starting from January 2019, CCS is proud to announce its affiliation with the International Cell Death Society. The journal now encourages submissions covering all aspects of cell death, including apoptotic and non-apoptotic mechanisms, cell death in model systems, autophagy, clearance of dying cells, and the immunological and pathological consequences of dying cells in the tissue microenvironment.